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GenomicsH3K27me3 ChIP-seq experiment in fruitfly testis somatic gonadal cells
In many metazoans, germ cells are separated from somatic lineages early in development and maintain their identity throughout life. Here we show that a Polycomb group (PcG) component, Enhancer of Zeste [E(z)] H3K27me3-specific methyltransferase, maintains germline identity in Drosophila adult testes...
ORGANISM(S): Drosophila melanogaster 
2014-05-02 | E-GEOD-53238 | biostudies-arrayexpress
TranscriptomicsMonovalent and unpoised status of most genes in undifferentiated cell-enriched Drosophila testis
We use male gonads isolated from a Drosophila strain that allows us to obtain enough cells at their primitive status as the starting material to study the endogenous chromatin structure of undifferentiated cells using ChIP-seq. We integrate the ChIP-seq data with RNA-seq data that measures the trans...
ORGANISM(S): Drosophila melanogaster 
2010-04-16 | E-GEOD-19325 | biostudies-arrayexpress
UnknownEffects and mechanisms of trifolin on attenuating hypertension-induced vascular smooth muscle cell proliferation and collagen deposition in vivo and in vitro.
Not available
S-EPMC12062450 | biostudies-literature
TranscriptomicsNegative reciprocal regulation between Sirt1 and Per2 modulates the circadian clock and aging (microarray expression)
Sirtuin 1 (SIRT1) is involved in both aging and circadian-clock regulation, yet the link between the two processes in relation to SIRT1 function is not clear. Using Sirt1-deficient mice, we found that Sirt1 and Period 2 (Per2) constitute a reciprocal negative regulation loop that plays important rol...
ORGANISM(S): Mus musculus 
2016-08-08 | E-GEOD-54436 | biostudies-arrayexpress
TranscriptomicsDynamic regulation of alternative splicing and chromatin structure in Drosophila gonads revealed by RNA-seq
Both transcription and post-transcriptional processes, such as alternative splicing, play crucial roles in controlling developmental programs in metazoans. Recently emerged RNA-seq method has brought our understanding of eukaryotic transcriptomes to a new level, because it can resolve both gene expr...
ORGANISM(S): Drosophila melanogaster 
2010-05-04 | E-GEOD-16960 | biostudies-arrayexpress
UnknownFrog vocal sacs-inspired soft acoustic system with continuously tunable resonance for sound emission and stethoscopic sensing.
Not available
S-EPMC12710722 | biostudies-literature
ProteomicsGut-liver axis calibrates intestinal stem cell fitness via PEDF
The gut and liver have been recognized to mutually communicate through the biliary tract, portal vein and systemic circulation, but it remains unclear how this gut-liver axis regulates intestinal physiology. Through hepatectomy, transcriptomics and proteomics profiling, we identified pigment epithel...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2023-03-03 | MSV000091409 | MassIVE
GenomicsPTIP promotes chromatin changes critical for immunoglobulin class switch recombination
Programmed genetic rearrangements in lymphocytes require transcription at antigen receptor genes to promote accessibility for initiating double-strand break (DSB) formation critical for DNA recombination and repair. Here we show that activated B cells deficient in the PTIP component of the MLL3 (mix...
ORGANISM(S): Mus musculus 
2010-08-25 | E-GEOD-20852 | biostudies-arrayexpress
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