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ProteomicsThe protective effect of Liquiritin in hypoxia/reoxygenation-induced disruption on blood brain barrier
Stroke is the second leading cause of death in human life health, but current treatment strategies are limited to thrombolytic therapy, and because of the tight time window, many contraindications, and only a very small number of people can benefit from it, new therapeutic strategies are needed to s...
ORGANISM(S): Homo Sapiens 
2021-04-25 | PXD025605 |
ProteomicsThe involvement of autophagy in mesaconitine-induced neurotoxicity in HT22 cells revealed through integrated transcriptomic, proteomic, and m6A epitranscriptomic profiling
In order to investigate the effects of mesaconitine treatment on protein expression, we carried out quantitative proteomic analysis to elucidate comprehensive protein changes in HT22 cells with or without mesaconitine treatment.
ORGANISM(S): Mus Musculus 
2024-05-03 | PXD052001 |
ProteomicsMechanism behind microalgal self-flocculation
Self-flocculation driven by gravity has shown as promising microalgal harvesting technology due to no requirement for additives and energies. However, the inherent unclear mechanism impedes its efficiency enhancement and commercial application. Current researches most only focus on the protein and c...
ORGANISM(S): Chlorella Sp. 
2021-02-05 | PXD024007 |
ProteomicsPACTS-assisted thermal proteome profiling identifies peptide-interacting proteins
The interaction between peptide ligands and protein receptors induced significant abundance changes of the target proteins, which was a signature to indicate the interaction and provide complementary information for the current thermal proteome profiling (TPP) technique
ORGANISM(S): Homo Sapiens 
2022-01-26 | PXD031246 |
ProteomicsAcetylated proteome data of young, old, FTO-knockdown and KAT8-overexpression human dermal fibroblasts
Acetylated proteome data of young human dermal fibroblasts (HDFs) [Young], old HDFs [Old], FTO-knockdown HDFs [shFTO], KAT8-overexpression HDFs [KAT8] and KAT8-overexpressed HDFs after FTO deprivation [shFTO_KAT8] were analysed by LC‒MS/MS.
ORGANISM(S): Homo Sapiens 
2024-12-20 | PXD059135 |
ProteomicsProteomic data of Fto-depleted skin and the control skin
Lentivirus expressing shRNA targeting Fto was intradermally injected into the back skin of wild-type C57BL/6j mice to locally knock down the expression of FTO in the skin. the proteome of control skin [shNC], Fto-depleted skin [shFto] were analysed by LC‒MS/MS.
ORGANISM(S): Mus Musculus 
2024-12-20 | PXD059134 |
ProteomicsTargeting ubiquitin-independent proteasome with small molecule increases susceptibility in pan-KRAS mutant cancers
Despite advances in the development of direct KRAS inhibitors, KRAS-mutant cancers continue to exhibit resistance to the currently available therapies. Here, we identified REGγ as a mutant KRAS-associated factor that enhances REGγ transcription through the KRAS intermediate NRF2, suggesting that the...
ORGANISM(S): Homo Sapiens 
2025-01-01 | PXD059364 |
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