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ProteomicsProteomic analysis of UCHL1 conditional knockout mice
Proteomic analysis of osteoclast precursor cells of UCHL1 conditional knockout mice and wild-type mice was performed
ORGANISM(S): Mus Musculus 
2024-08-14 | PXD052578 |
ProteomicsProteomic Profiling of Mycobacterium tuberculosis in Response to ILE Treatment
This study aims to elucidate the global proteomic changes in Mycobacterium tuberculosis upon treatment with the novel compound ilamycin E(ILE), which targets the Clp protease system. Label-free quantitative proteomics was employed to assess differential protein expression after ILE exposure. The res...
ORGANISM(S): Mycobacterium tuberculosis H37Ra 
2026-02-09 | PXD066355 | Pride
Mycobacterium tuberculosis Tuberculosis Ilamycin e 
ProteomicsNuclear condensation of CDYL links histone crotonylation and cystogenesis in autosomal dominant polycystic kidney disease
We identify the Kcr sites on histones that are targeted by CDYL in ADPKD cells (WT9-12 cells). We chose to knock out CDYL in WT 9-12 cells (CDYL KO) through CRISPR/Cas9-mediated gene editing to increase the overall levels of histone Kcr. We quantified Kcr modifications on different histone residues ...
ORGANISM(S): Homo Sapiens 
2022-01-17 | PXD031029 |
ProteomicsIdentification of tumor membrane proteins
Identification of chemotherapy-treated B16-F10 tumor membrane proteins
ORGANISM(S): Mus Musculus 
2024-08-28 | PXD055424 |
ProteomicsHigh-fat diet alters retinal lipid composition and gene expression networks in mice
To reveal whether a long-term HFD alters gene expression levels in the retina, we used 4D-label free mass spectrometry to quantify proteins in the whole retinas of HFM and age-mated NM. As the liver plays a crucial role in metabolism of the whole body, HFD has a huge impact on gene expression in the...
ORGANISM(S): Mus Musculus 
2024-05-14 | PXD052242 |
ProteomicsDrosophila tracheal cell mass spectrum data
Proteomics of the trachea surface of third instar Drosophila larvae
ORGANISM(S): Drosophila Melanogaster 
2024-02-02 | PXD049142 |
ProteomicsRIPK2 promotes colorectal cancer metastasis by protecting YAP degradation from ITCH-mediated ubiquitination
Colorectal cancer (CRC) is a leading cause of cancer death. RIPK2 is identified as a poor prognostic marker, promoting metastasis via bacterial invasion. High RIPK2-expressing tumor cells show enhanced invasiveness. This dataset comprises quantitative proteomic profiles of colorectal cancer (CRC) ce...
ORGANISM(S): Homo Sapiens 
2025-03-03 | PXD061372 |
ProteomicsGlobal phosphoproteomic analysis of mouse spermatocytes identified key kinases regulating meiosis
Protein phosphorylation, as one of the most important post-translational modifications, exerts crucial roles in regulating meiosis. However, there is a lack of systemic phosphoproteomic and functional analysis of phosphorylation in the meiosis of spermatocytes. To characterize the phosphorylation ev...
ORGANISM(S): Mus Musculus 
2022-03-07 | PXD032089 |
ProteomicsDDX39B K63-linked ubiquitination mediated by TRIM28 promotes NSCLC metastasis by enhancing ECAD lysosomal degradation
DDX39B interacted with E3 ubiquitin ligase TRIM28 and underwent TRIM28-mediated K63-linked ubiquitination at Lys241, Lys384, and Lys398, leading to DDX39B protein stabilization and upregulation.
ORGANISM(S): Homo Sapiens 
2025-06-10 | PXD064812 |
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