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UnknownCK1ε/SRSF10 axis regulates the alternative splicing of Bcl-x in lung cancer cells.
The dysregulation of Bcl-x alternative splicing is associated with tumor development and chemoresistance. However, the underlying molecular mechanisms of Bcl-x splicing are still not well-defined. Here, we demonstrated that casein kinase 1ε (CK1ε) was involved in the regulation of Bcl-x alternative ...
S-EPMC12391806 | biostudies-literature
UnknownIL-17 sustains the plasma cell response via p38-mediated Bcl-xL RNA stability in lupus pathogenesis.
Recent studies have demonstrated a central role for plasma cells in the development of autoimmune diseases, such as systemic lupus erythematosus (SLE). Currently, both the phenotypic features and functional regulation of autoreactive plasma cells during SLE pathogenesis remain largely unclear. In th...
S-EPMC8245411 | biostudies-literature
UnknownGZD824 suppresses the growth of human B cell precursor acute lymphoblastic leukemia cells by inhibiting the SRC kinase and PI3K/AKT pathways.
Available therapeutic options for advanced B cell precursor acute lymphoblastic leukemia (pre-B ALL) are limited. Many lead to neutropenia, leaving patients at risk of life-threatening infections and result in bad outcomes. New treatment options are needed to improve overall survival. We previously ...
S-EPMC5675611 | biostudies-literature
ProteomicsUtilization of cross-linking mass spectrometry (XL-MS) for structural analysis of the ApoD-CD36 protein interaction
Structural analysis of the ApoD-CD36 complex by XL-MS.
ORGANISM(S): Homo Sapiens 
2025-11-20 | PXD070975 |
ProteomicsSpatiotemporal and global profiling of DNA-protein interactions enables discovery of low-affinity transcription factors
Precise dissection of DNA-protein interactions is essential for elucidating recognition basis, dynamics, and gene regulation mechanism. However, global profiling of weak and dynamic DNA-protein interactions remains a long-standing challenge. Here, we establish light-induced lysine (K) enabled crossl...
ORGANISM(S): Homo Sapiens 
2023-01-03 | PXD039229 |
ProteomicsMice Hippocampus neuron HT22 LC-MS
Ketone 3-hydroxybutyrate (3OHB) has been proved to be a neuroprotective endogenous molecule in multiple neurodegenerative diseases, but the detailed mechanisms of action has not been fully uncovered. Here, we employed a quantitative proteomics approach to assess the global protein expression pattern...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-10 | PXD008053 | Pride
Neuron Central nervous system Proteomics Bivalent chromatin Histone lysine hydroxybutyrylation Ht22 Beta-hydroxybutyrate Mice Transcriptomics 
UnknownBombyx mori Nuclear Polyhedrosis Virus (BmNPV) Induces Host Cell Autophagy to Benefit Infection.
Bombyx mori nuclear polyhedrosis virus (BmNPV) is an important pathogen of silkworms. Despite extensive studies in recent decades, the interaction between BmNPV and host cells is still not clearly understood. Autophagy is an intrinsic innate immune mechanism and it controls infection autonomously in...
S-EPMC5795427 | biostudies-literature
UnknownSerum ammonia variation predicts mortality in patients with hepatitis B virus-related acute-on-chronic liver failure.

Background

Hyperammonemia is critical to the development of hepatic encephalopathy (HE) and is associated with mortality in end-stage liver disease. This study investigated the clinical value of ammonia variation in hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) patients...
S-EPMC10725913 | biostudies-literature
UnknownSex Differences in Genetic Associations With Longevity.

Importance

Sex differences in genetic associations with human longevity remain largely unknown; investigations on this topic are important for individualized health care.

Objective

To explore sex differences in genetic associations with longevity.

Design setting and participants

S-EPMC6173523 | biostudies-literature
UnknownSalvianolic acid A from Salvia miltiorrhiza identified as a cap-dependent endonuclease inhibitor for pathogenic arenaviruses.
Negative-stranded segmented RNA viruses (NSVs) employ a cap-snatching mechanism for transcription, which makes cap-dependent endonuclease (CEN) an attractive target for drug development. Pathogenic arenaviruses pose a serious threat to humans, yet no approved treatments exist, underscoring the impor...
S-EPMC12764842 | biostudies-literature
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