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ProteomicsUSP36 stabilizes nucleolar Snail1 to promote ribosome biogenesis and cancer cell survival upon ribotoxic stress
Tumor growth requires elevated ribosome biogenesis. Targeting ribosomes is an important strategy for cancer therapy. The ribosome inhibitor, homoharringtonine (HHT), is used for the clinical treatment of leukemia, yet it is ineffective for the treatment of solid tumors, the reasons for which remain ...
ORGANISM(S): Homo sapiens (Human) 
2023-09-26 | PXD045622 | Pride
Usp36  snail1  ribosome biogenesis  ribotoxic stress 
ProteomicsInhibition of MBTPS1 enhances antitumor immunity and potentiates anti-PD-1 immunotherapy
In this project, we transfected MC38 cells with Flag-tagged Mbtps1 or vector control. After that, we performed immunoprecipitation–mass spectrometry analysis to search the interacting proteins of MBTPS1. In our study, We observed that the loss of membrane-bound transcription factor site-1 protease ...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) Mus musculus (Mouse) 
2025-04-11 | PXD053978 | Pride
Lc-msms Mouse Mc38 cell 
MetabolomicsMultiple biochemical indices and metabolomics of Clonorchis sinensis provide a novel interpretation of biomarkers

BACKGROUND: Clonorchiasis, an infectious disease caused by the liver fluke Clonorchis sinensis, may lead to the development of liver and gallbladder diseases, and even cholangiocarcinoma (CCA). However, the pathogenesis, host-pathogen interaction, and diagnostic markers ...

2022-06-24 | MTBLS3306 | MetaboLights
UnknownUSP36 stabilizes nucleolar Snail1 to promote ribosome biogenesis and cancer cell survival upon ribotoxic stress.
Not available
S-EPMC10575996 | biostudies-literature
UnknownDynamic changes of CSF sPDGFRβ during ageing and AD progression and associations with CSF ATN biomarkers.
Not available
S-EPMC8760673 | biostudies-literature
UnknownRNA-Seq and 16S rRNA Reveals That Tian-Dong-Tang-Gan Powder Alleviates Environmental Stress-Induced Decline in Immune and Antioxidant Function and Gut Microbiota Dysbiosis in Litopenaeus vannami.
Not available
S-EPMC10295192 | biostudies-literature
UnknownProphylactic phage administration provides a time window for delayed treatment of vancomycin-resistant Enterococcus faecalis in a murine bacteremia model.
Not available
S-EPMC11802572 | biostudies-literature
ProteomicsProteomics of adult and metacercariae of Metorchis orientalis
We used proteomics to compare the differential protein expression between adult and metacercariae stage of Metorchis orientalis. Three biological replicates were set up at each stage for protein analysis using Nano HPLC.
ORGANISM(S): Metorchis Orientalis 
2021-10-08 | PXD029022 |
ProteomicsProteogenomic characterization analysis of human large cell lung cancer
Current clinical therapy of non-small cell lung cancer depends on histo-pathological classification. This approach poorly predicts clinical outcome for individual patients. Proteogenomic characterization analysis holds promise to improve clinical stratification, thus paving the way for individualize...
ORGANISM(S): Homo Sapiens 
2019-01-16 | PXD012393 |
UnknownGq activity- and β-arrestin-1 scaffolding-mediated ADGRG2/CFTR coupling are required for male fertility.
Not available
S-EPMC5839696 | biostudies-literature
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