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ProteomicsSialo-glycoproteome of Human lung cancer cell by LC-MSMS
Alterations in protein glycosylation, especially the terminal sialylation, are closely correlated with physiological and pathological regulation. Due to the low ionization efficiency of sialo-glycopeptides and frequently observed dissociation of sialic acid residues during mass spectrometry analysis...
ORGANISM(S): Homo sapiens (Human) 
2022-02-25 | PXD010456 | Pride
Sialo-glycoproteome Glycoproteome Human lung cancer 
ProteomicsEnhanced Proteomic Coverage in Tissue Microenvironment by Immune Cell Subtype Library-assisted DIA-MS
The objective of the protject is to develop an immune cell-enrich library-assisted DIA method that enables the comprehensive identification and quantification of immunological proteins from micro-scale samples with high sensitivity. In the project, six immune cell subtype-specific libraries includin...
ORGANISM(S): Mus Musculus (mouse) 
2025-01-18 | PXD048670 | JPOST Repository
ProteomicsTKI-resistant T790M EGFR Mutation Rewired EGFR Translocation Routes through Switching Interactome in Non-Small Cell Lung Cancer
Epidermal growth factor receptor (EGFR) harboring active mutations, Del19 and L858R, are most common oncogenic mutations in in non-small cell lung cancer (NSCLC) patients. The preferred treatment at first line is tyrosine kinase inhibitor (TKI) administration while the TKI-resistance usually develop...
ORGANISM(S): Homo Sapiens (human) 
2023-05-31 | PXD034228 | JPOST Repository
ProteomicsCerebrospinal Fluid Proteome Map Reveals Molecular Signatures of Reversible Cerebral Vasoconstriction Syndrome
The project aims to identify differentially expressed proteins that could be of biomarker value for patients with reversible cerebral vasoconstriction syndrome (RCVS). An RCVS-CSF spectral library resource was established from DDA/DIA analysis of cerebrospinal fluids of 21 RCVS patients and 20 sex-a...
ORGANISM(S): Homo Sapiens (human) 
2025-10-14 | PXD042810 | JPOST Repository
ProteomicsTemporal regulation of Lsp1 O-GlcNAcylation and phosphorylation duringactivated Bcellsapoptosis
Here, we decipher the molecular mechanisms bridging B cell activation and apoptosis mediated by post-translational modification(PTM). We found that O-GlcNAcase inhibition enhances B cell activation and apoptosisinduced by B cell receptor (BCR)cross-linking. This proteome-scale analysis of the functi...
ORGANISM(S): Mus musculus (Mouse) 
2016-09-26 | PXD003788 | Pride
Phosphoproteome B cell O-glcnacylation Apoptosis 
ProteomicsMining Missing Protein Landscape in Subcellular Proteome of Human Embryonic Stem Cells
Human embryonic stem cells (hESCs) have capacity of self-renewal and multi-lineage differentiation into derivatives of three germ layers that are of clinical importance for regeneration medicine. Despite the significant progress of hESCs study for clinical application, factors responsible for mainta...
ORGANISM(S): Homo Sapiens (human) 
2019-05-20 | PXD009840 | JPOST Repository
ProteomicsLarge-scale determination of absolute phosphorylation stoichiometries in human cells by motif-targeting quantitative proteomics
We developed a motif-based isotopic quantitative method for determination of phosphorylation stoichiometry based on kinase selection.
ORGANISM(S): Homo sapiens (Human) 
2015-03-30 | PXD000728 | Pride
Motif Imac Drug resistance Phosphorylation stoichiometry Lung cancer 
ProteomicsPhosphoproteomic analyses reveal that galectin-1 augments the dynamics of B-cell receptor signaling
we applied label-free quantitative phosphoproteomic analysis to delineate the dynamics of galectin-1-induced signaling in comparison with the first systematic phosphorylation-mediated signaling network in B cell activation by anti-IgM treatment.
ORGANISM(S): Mus musculus (Mouse) 
2016-03-15 | PXD000762 | Pride
B-cell receptor Phosphoproteome Galectin-1 B-cell activation Lc-ms/ms 
ProteomicsPhosphoproteomics landscape of lung DTP
Osimertinib is the first-line therapy for EGFR-mutated non-small cell lung cancer, but acquired resistance commonly develops, linked to a drug-tolerant persister (DTP) cell state that promotes survival and eventual resistance. Using data-independent acquisition mass spectrometry (DIA-MS), we mapped ...
ORGANISM(S): Homo sapiens (Human) 
2025-11-10 | PXD058009 | Pride
Lc-msms Lung Huamn Dtp 
ProteomicsRapid High-pH Reverse Phase StageTip for Sensitive Small-Scale Membrane Proteomic Profiling
Membrane proteins are crucial targets for cancer biomarker discovery and drug development. However, in addition to the inherent challenges of hydrophobicity and low abundance, complete membrane proteome coverage of clinical specimen is usually hindered by the requirement of large amount of starting ...
ORGANISM(S): Rattus rattus (Black rat) Homo sapiens (Human) 
2015-11-16 | PXD001548 | Pride
High-ph reverse phase stagetip Membrane proteins Lung cancer 
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