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Insufficient leaf photosynthesis promotes sheath NSC transport to the panicle during grain filling. SnRK1 regulates assimilate distribution between plant tissues and organs. However, the mechanism by which SnRK1 regulates sheath NSC transport to the panicle and its response to limited leaf assimilat...
ORGANISM(S): Oryza sativa (Rice) 
2022-03-18 | PXD024675 | Pride
To probe into the molecular mechanism underlying the onset of choroidal neovascularization (CNV), integrated transcriptomic and proteomic analyses of the retinas in mice with laser-induced CNV were performed by using RNA sequencing and tandem mass tag.
ORGANISM(S): Mus Musculus 
2023-02-09 | PXD039971 |
We artificially infected Sprague Dawley (SD) rats and Kunming (KM) mice with type II Toxoplasma gondii (T. gondii) strain (Prugniaud, Pru) to generate toxoplasmosis, which is a fatal disease mediated by T. gondii invasion in the central nervous system (CNS) with unknown mechanisms. We aimed to explo...
ORGANISM(S): Rattus Norvegicus Mus Musculus 
Glioblastoma (GBM) is the most malignant tumor of the central nervous system. Current first-line post-surgery regimens for GBM including radiotherapy and temozolomide (TMZ) chemotherapy show very limited efficacy, with a median overall survival of only 15 months. Therefore, the development of therap...
ORGANISM(S): Homo Sapiens 
2022-10-11 | PXD037301 |
Schistosomiasis, a zoonotic parasitic disease caused by trematodes of the genus Schistosoma, represents a significant zoonotic parasitic disease that affects over 200 million people across 78 countries, with a substantial burden on public health systems globally. The phenomenon of male-induced sexua...
ORGANISM(S): Schistosoma Mansoni 
Proteomics data of targets identification of Danhong injection(10plex TMT)
ORGANISM(S): Homo Sapiens 
Through whole-exome sequencing of 800 patients with asthenozoospermia, we identified biallelic TEX44 variants in six individuals, all of whom exhibited defective mitochondrial sheath assembly and impaired sperm motility. Using Tex44 knockout mice, we demonstrated that TEX44 interacts with carnitine ...
ORGANISM(S): Mus Musculus 
2025-02-20 | PXD060989 |
The transition from pluripotent to somatic states marks a critical event in mammalian development, but remains largely unresolved. Here we report the identification of SS18 as a regulator for pluripotent to somatic transition or PST by CRISPR-based whole genome screens. Mechanistically, SS18 forms m...
ORGANISM(S): Mus Musculus 
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