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ProteomicsGNL3 orchestrates AR transcriptional programs to drive castration-resistant prostate cancer and immune evasion
Androgen receptor (AR) signaling is a primary oncogenic driver of castration-resistant prostate cancer (CRPC), yet the mechanism remains incompletely understood. Dysregulation of the AR co-regulatory network has emerged as a key driver of castration resistance. To identify AR-interacting proteins li...
ORGANISM(S): Homo sapiens (Human) 
2026-06-08 | PXD067138 | Pride
Castration-resistant prostate cancer Ar coregulator Immunosuppression Gnl3 
ProteomicsAndrogen receptor RIME in prostate cancer cells
Androgen receptor (AR) is a master transcription factor that drives prostate cancer (PCa) development and progression. Alterations in the expression or activity of AR coregulators significantly impact the disease's outcome. To identify all the essential components of the AR coregulator complex, we u...
ORGANISM(S): Homo sapiens (Human) 
2022-07-12 | PXD031273 | Pride
Androgen receptor Prostate cancer Rime Cofactors 
GenomicsTMPRSS2-ERG, HDACs and EZH2 are involved in an AR-centric transcriptional circuitry that calibrates androgenic response for prostate cancer progression (ChIP-Seq data)
Deregulation of the Androgen Receptor (AR) transcriptional network is a common hallmark in prostate cancers. To achieve its precise transcriptional role, AR needs to co-operate specifically with a plethora of cofactors. In prostate cancers, AR transcription collaborators are frequently aberrantly ov...
ORGANISM(S): Homo sapiens 
2012-04-26 | E-GEOD-28950 | biostudies-arrayexpress
TranscriptomicsTMPRSS2-ERG, HDACs and EZH2 are involved in an AR-centric transcriptional circuitry that calibrates androgenic response for prostate cancer progression (gene expression data)
Deregulation of the Androgen Receptor (AR) transcriptional network is a common hallmark in prostate cancers. To achieve its precise transcriptional role, AR needs to co-operate specifically with a plethora of cofactors. In prostate cancers, AR transcription collaborators are frequently aberrantly ov...
ORGANISM(S): Homo sapiens 
2012-04-26 | E-GEOD-28948 | biostudies-arrayexpress
GenomicsNKX3-1, a Novel Transcriptional Factor of AR, Promotes Prostate Cancer Cell Survival via RAB3B GTPase-mediated protein trafficking
Androgen receptor (AR) orchestrates an intricate transcriptional regulatory network that governs prostate cancer initiation, development and progression. To understand this network in detail, we generated genome-wide maps of AR occupancy by ChIP-seq in LNCaP cells. We found NKX3-1, an androgen-depen...
ORGANISM(S): Homo sapiens 
2011-11-16 | E-GEOD-28264 | biostudies-arrayexpress
ProteomicsLow Dose Radiation Induces New Protein Synthesis that Promotes Cancer Radiotherapy Resistance
Radiotherapy (RT) is a cornerstone of cancer treatment; however, its efficacy is frequently hampered by its adverse effects on normal tissues. By studying the effects of high-dose radiotherapy (HDRT) and low-dose radiotherapy (LDRT), we found that cancer cells adapt distinct responses to these doses...
ORGANISM(S): Homo Sapiens 
2026-02-26 | PXD074928 |
GenomicsTissue-type specific estrogen signaling in breast and uterine cancer cells
Estrogen receptors play critical roles in both the normal physiological, and disease states of numerous tissues, including breast and uterus. Estrogen receptor alpha (ER) can activate or repress the expression of target genes upon estrogen stimulation. In order to better understand the transcription...
ORGANISM(S): Homo sapiens 
2011-01-05 | E-GEOD-23893 | biostudies-arrayexpress
TranscriptomicsActivator protein-2γ is a critical determinant of estrogen receptor interactome formation and gene transcription in breast cancer [expression]
Estrogen receptor α (ERα) is key player in the progression of breast cancer. ERα binds to DNA and mediates long-range chromatin interactions throughout the genome, but the underlying mechanism in this process is unclear. Here, we show that AP-2 motifs are highly enriched in the ERα binding sites...
ORGANISM(S): Homo sapiens 
2011-06-02 | E-GEOD-26740 | biostudies-arrayexpress
GenomicsActivator protein-2M-NM-3 is a critical determinant of estrogen receptor interactome formation and gene transcription in breast cancer [ChIP-Seq]
Estrogen receptor M-NM-1 (ERM-NM-1) is key player in the progression of breast cancer. ERM-NM-1 binds to DNA and mediates long-range chromatin interactions throughout the genome, but the underlying mechanism in this process is unclear. Here, we show that AP-2 motifs are highly enriched in the ERM-NM...
ORGANISM(S): Homo sapiens 
2011-06-03 | E-GEOD-23852 | biostudies-arrayexpress
GenomicsCENTDIST: Discovery of Co-associated Factors by Motif Distribution
Transcription factors (TFs) do not function alone but work together with other TFs (called co-TFs) in a combinatorial fashion to precisely control the transcription of target genes. Mining co-TFs is thus important to understand the mechanism of transcriptional regulation. Although existing methods c...
ORGANISM(S): Homo sapiens 
2012-04-25 | E-GEOD-28857 | biostudies-arrayexpress
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