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TranscriptomicsInterferon alfa regulated gene expression in patients initiating interferon treatment for chronic hepatitis C
Interferon alfa (IFN-alpha) is an approved therapeutic agent for chronic hepatitis C. To directly characterize the effects of IFN-alpha in humans, we used microarrays to profile gene expression in peripheral blood mononuclear cells (PBMCs) from hepatitis C patients treated with IFN-alpha. Seven pati...
ORGANISM(S): Homo sapiens 
2006-01-31 | E-GEOD-4134 | biostudies-arrayexpress
UnknownSingle-molecule sequencing reveals a large population of long cell-free DNA molecules in maternal plasma.
Not available
S-EPMC8685924 | biostudies-literature
ProteomicsPhosphoproteomic analysis of signaling downstream of p85β
p85β is a regulatory subunit of phosphatidylinositol 3-kinase. The signaling mechanism of p85β is poorly understood. Quantitative mass spectrometry-based phosphoproteomic analysis was therefore performed to reveal proteins with an altered phosphorylation status upon PIK3R2 depletion in ovarian cance...
ORGANISM(S): Homo sapiens (Human) 
2020-05-08 | PXD018449 | Pride
Phosphoproteomics Pi3k P85 
ProteomicsLC-MS/MS proteomic analysis of mouse brown adipose tissues
This project aims to identify the proteins present in RNA granules of brown adipose tissue upon exposure to cold challenge. Wild type C57BL/6J mice were born and raised at thermoneutrality and were then subjected to cold exposure for 90 minutes. Brown adipose tissues were collected, and the protein ...
ORGANISM(S): Mus musculus (Mouse) 
2023-11-23 | PXD044433 | Pride
Brown adipose tissue Mouse Cold challenge Rna granules 
ProteomicsGNL3 orchestrates AR transcriptional programs to drive castration-resistant prostate cancer and immune evasion
Androgen receptor (AR) signaling is a primary oncogenic driver of castration-resistant prostate cancer (CRPC), yet the mechanism remains incompletely understood. Dysregulation of the AR co-regulatory network has emerged as a key driver of castration resistance. To identify AR-interacting proteins li...
ORGANISM(S): Homo sapiens (Human) 
2026-06-08 | PXD067138 | Pride
Castration-resistant prostate cancer Ar coregulator Immunosuppression Gnl3 
MetabolomicsMetabolomics Analysis Reveals Tissue-Specific Metabolite Compositions in Leaf Blade and Traps of Carnivorous Nepenthes Plants
Nepenthes is a genus of carnivorous plants that evolved a pitfall trap, the pitcher, to catch and digest insect prey to obtain additional nutrients. Each pitcher is part of the whole leaf, together with a leaf blade. These two completely different parts of the same organ were studied separately in a...
2020-07-10 | MTBLS1783 | MetaboLights
ProteomicsSystematic profiling of lysine lactylation proteome reveals distinct changes in lactylation between the parental AGS cells and cisplatin-resistant AGS cells
Lactate enable to cause a novel post-translational modification, lactylation of proteins. We are interested in exploring whether lactate modulates DNA-damaging agents resistance in the form of lactylation. To gain a global view of DNA-damaging agents resistance-related lactylation, especially Kla of...
ORGANISM(S): Homo sapiens (Human) 
2024-05-09 | PXD050906 | Pride
Lysine lactylation 
UnknownDirecting differentiation of human induced pluripotent stem cells toward androgen-producing Leydig cells rather than adrenal cells.
Not available
S-EPMC6859353 | biostudies-literature
MetabolomicsDifferential role of sphingomyelin in influenza virus, rhinovirus and SARS-CoV-2 infection of Calu-3 cells
Host cell lipids play a pivotal role in the pathogenesis of respiratory virus infection. However, a direct comparison of the lipidomic profile of influenza virus and rhinovirus infections is lacking. In this study, we first compared the lipid profile of influenza virus and rhinovirus infection in a ...
2022-11-15 | MTBLS2352 | MetaboLights
ProteomicsProteomic profiling of RNase III-dependent asRNA regulation in E. coli
In an effort to determine if the RNase III-dependent asRNA regulation had an effect on protein production in E. coli we conducted two TMT 6-plex experiments comparing cultures of wildtype E. coli, rnc-14, rnc-38, hfq in the stationary and exponential phase.
ORGANISM(S): Escherichia coli 
2020-06-18 | PXD011180 | Pride
E. coli Antisense rnas Rnase iii 
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