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ProteomicsA p85 Isoform Switch Enhances PI3K Activation on Endosomes by a MAP4- and PI3P-dependent Mechanism
PI3K is a heterodimer of p110 catalytic and p85 adaptor subunits that is activated by agonist-stimulated receptor tyrosine kinases. Although p85 recruits p110 to activated receptors on membranes, p85 loss, which occurs commonly in cancer, paradoxically promotes agonist-stimulated PI3K/Akt signaling....
ORGANISM(S): Homo sapiens (Human) 
2024-10-17 | PXD050817 | Pride
P85 Pi3k Akt Endosomes P110 Map4 Pi3p 
GenomicsPTPN13 Contributes to Ebola Virus Induced Immune Dysregulation via dephosphorylation of IRF3 and PI3K-p85
PTPN13 Contributes to Ebola Virus Induced Immune Dysregulation via dephosphorylation of IRF3 and PI3K-p85
PRJNA1433504 | ENA
UnknownRegulation of Class IA PI 3-kinases: C2 domain-iSH2 domain contacts inhibit p85/p110alpha and are disrupted in oncogenic p85 mutants.
Not available
S-EPMC2787125 | biostudies-literature
ProteomicsHuman HEK293 Gemin5 clinical variants LC-MSMS
Identification of cellular proteins interacting with Gemin5 variants found in patients with neurological disorders. P85 C-terminal fragment of Gemin5 has been used to purify the protein complexes associated by Tandem Affinity Purification. The study has been performed using two biological replicates...
ORGANISM(S): Homo sapiens (Human) 
2022-04-06 | PXD028959 | Pride
Human Gemin5 Lc-msms Clinical variants Hek293 
UnknownIKK-β mediates hydrogen peroxide induced cell death through p85 S6K1.
Not available
S-EPMC3554328 | biostudies-literature
TranscriptomicsPTPN13 Contributes to Ebola Virus Induced Immune Dysregulation via dephosphorylation of IRF3 and PI3K-p85
Ebola virus disease (EVD) is characterized by immune dysregulation and damaging hyperinflammation. We aimed to characterize the signaling pathways and regulatory mechanisms dysregulated during EVD. To avoid hyperinflammation, innate immune signaling is regulated by posttranslational modifications, i...
ORGANISM(S): Homo sapiens 
2026-08-12 | GSE324141 | GEO
Unknownp85 Associates with unphosphorylated PTEN and the PTEN-associated complex.
Not available
S-EPMC2747981 | biostudies-literature
UnknownCbl ubiquitination of p85 is essential for Epo-induced EpoR endocytosis.
Not available
S-EPMC3854114 | biostudies-literature
GenomicsSMS2 suppresses hepatocellular carcinogenesis by impairing p85/p110 interaction
SMS2 suppresses hepatocellular carcinogenesis by impairing p85/p110 interaction
PRJNA842681 | ENA
ProteomicsHuman HEK293 Gemin5 phosphorylation site T897 mutants LC-MSMS
Identification of cellular proteins interacting with Gemin5 phosphorylation mutants in T897 residue. We used the T897A mutant as phosphorylation defective protein and the T897E mutant as phosphomimetic. P85 C-terminal fragment of Gemin5 has been used to purify the protein complexes associated by Tan...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD035227 | Pride
Human Gemin5 Hek293 Phosphorylation 
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