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TranscriptomicsTargeting the Phosphoinositide 3-Kinase p110-alpha Isoform Impairs Cell Proliferation, Survival and Tumor Growth in Small Cell Lung Cancer
Purpose: The phosphoinositide 3-kinase (PI3K) pathway is fundamental for cell proliferation and survival and is frequently altered and activated in neoplasia, including carcinomas of the lung. In this study we investigated the potential of targeting the catalytic class IA PI3K isoforms in small cell...
ORGANISM(S): Homo sapiens 
2012-12-01 | E-GEOD-40564 | biostudies-arrayexpress
ProteomicsStructure of the phosphoinositide 3-kinase p110-p101 complex reveals molecular mechanism of GPCR activation
The class IB phosphoinositide 3-kinase (PI3K), PI3K, is a master regulator of immune cell function, and is a promising drug target for both inflammatory diseases and cancer. Critical to PI3K function is the association of the p110 catalytic subunit to either a p101 or p84 regulatory subunit, which ...
ORGANISM(S): Homo sapiens (Human) 
2021-09-22 | PXD025209 | Pride
Hdx Cryo-em Gpcr Pik3g 
ProteomicsA p85 Isoform Switch Enhances PI3K Activation on Endosomes by a MAP4- and PI3P-dependent Mechanism
PI3K is a heterodimer of p110 catalytic and p85 adaptor subunits that is activated by agonist-stimulated receptor tyrosine kinases. Although p85 recruits p110 to activated receptors on membranes, p85 loss, which occurs commonly in cancer, paradoxically promotes agonist-stimulated PI3K/Akt signaling....
ORGANISM(S): Homo sapiens (Human) 
2024-10-17 | PXD050817 | Pride
P85 Pi3k Akt Endosomes P110 Map4 Pi3p 
Proteomicsp110 Alpha and Beta TAP
Tandem Affinity Purification of p110-Alpha and p110-Beta
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-06-07 | MSV000081148 | MassIVE
TranscriptomicsMicrorna expression profile in ADAR1 p110 overexpression
The change in Microrna expression profile in ADAR1 p110 overexpression.
ORGANISM(S): Homo sapiens 
2022-03-31 | E-MTAB-11574 | biostudies-arrayexpress
TranscriptomicsA constitutively activated form of the p110 beta isoform of PI3-kinase induces prostatic intraepithelial neoplasia in mice
The global gene expression profiles of ventral prostates of wild type mice and p110 beta transgenic mice. normal prostate vs. prostate cancer induced by the overexpression of the active allele of p110 beta
ORGANISM(S): Mus musculus 
2010-06-08 | E-GEOD-21543 | biostudies-arrayexpress
UnknownMycoplasma genitalium adhesin P110 binds sialic-acid human receptors.
Not available
S-EPMC6203739 | biostudies-literature
UnknownDecoupling expression and editing preferences of ADAR1 p150 and p110 isoforms.
Not available
S-EPMC8000508 | biostudies-literature
UnknownCHK2 kinase promotes pre-mRNA splicing via phosphorylating CDK11(p110).
Not available
S-EPMC4131284 | biostudies-literature
Unknownp110, a novel human U6 snRNP protein and U4/U6 snRNP recycling factor.
Not available
S-EPMC126028 | biostudies-literature
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