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ProteomicsPhosphatidylinositol 3-phosphate (PI3P) interactome analysis under varied iron conditions in Candida glabrata.
The project is aimed at identifying proteins that interact with PI3P in low-iron, regular-iron and high-iron grown Candida glabrata cells.
ORGANISM(S): Candida glabrata (Yeast) (Torulopsis glabrata) 
2024-02-19 | PXD042058 | Pride
Bathophenanthroline disulfonate (bps) Lc-ms/ms. Candida glabrata Phosphatidylinositol 3-phosphate (pi3p) 
ProteomicsHydrogen Deuterium Exchange of PIKfyve construct with PI3P vesicles and inhibitors
We used HDXMS to study the confomational changes induced in a PIKfyve construct upon binding PI3P membrane and a variety of inhibitors. Here we showed a significant protection in deuterium exchange upon binding all inhibitors, and regions of protection and exposure upon binding PI3P membrane.
ORGANISM(S): Homo sapiens (Human) 
2025-10-15 | PXD044706 | Pride
Hdxms Apy0201 Ym-201636 Momipp Pikfyve Pi3p Apilimod 
ProteomicsIn vitro reconstitution of Sgk3 activation by phosphatidylinositol-3-phosphate
Serum- and glucocorticoid-regulated kinase 3 (Sgk3) is activated by the phospholipid 19 phosphatidylinositol-3-phosphate (PI3P) downstream of growth factor signaling and 20 by Vps34-mediated PI3P production during autophagy. Upregulation of Sgk3 activity 21 has been linked to a number of human cance...
ORGANISM(S): Homo sapiens (Human) 
2021-09-22 | PXD025327 | Pride
Kinase Sgk3 Hdx-ms Pi3p 
UnknownExploring the Role of PI3P in Platelets: Insights from a Novel External PI3P Pool.
Not available
S-EPMC10135486 | biostudies-literature
ProteomicsA p85 Isoform Switch Enhances PI3K Activation on Endosomes by a MAP4- and PI3P-dependent Mechanism
PI3K is a heterodimer of p110 catalytic and p85 adaptor subunits that is activated by agonist-stimulated receptor tyrosine kinases. Although p85 recruits p110 to activated receptors on membranes, p85 loss, which occurs commonly in cancer, paradoxically promotes agonist-stimulated PI3K/Akt signaling....
ORGANISM(S): Homo sapiens (Human) 
2024-10-17 | PXD050817 | Pride
P85 Pi3k Akt Endosomes P110 Map4 Pi3p 
UnknownPI3P regulates multiple stages of membrane fusion.
Not available
S-EPMC10011722 | biostudies-literature
UnknownPI3P binding by Atg21 organises Atg8 lipidation.
Not available
S-EPMC4388602 | biostudies-literature
UnknownElevating PI3P drives select downstream membrane trafficking pathways.
Not available
S-EPMC8120694 | biostudies-literature
UnknownEngineering crop Phytophthora resistance by targeting pathogen-derived PI3P for enhanced catabolism.
Not available
S-EPMC10030320 | biostudies-literature
UnknownPI3P-dependent regulation of cell size and autophagy by phosphatidylinositol 5-phosphate 4-kinase.
Not available
S-EPMC10267561 | biostudies-literature
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