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ProteomicsHydrogen Deuterium Exchange of PIKfyve construct with PI3P vesicles and inhibitors
We used HDXMS to study the confomational changes induced in a PIKfyve construct upon binding PI3P membrane and a variety of inhibitors. Here we showed a significant protection in deuterium exchange upon binding all inhibitors, and regions of protection and exposure upon binding PI3P membrane.
ORGANISM(S): Homo sapiens (Human) 
2025-10-15 | PXD044706 | Pride
Hdxms Apy0201 Ym-201636 Momipp Pikfyve Pi3p Apilimod 
GenomicsPIKfyve controls dendritic cell function and tumor immunity I
PIKfyve controls dendritic cell function and tumor immunity I
PRJNA986528 | ENA
GenomicsPIKfyve controls dendritic cell function and tumor immunity II
PIKfyve controls dendritic cell function and tumor immunity II
PRJNA986531 | ENA
GenomicsPIKfyve-regulated lipid metabolism as a therapeutic vulnerability in neuroendocrine prostate cancer
PIKfyve-regulated lipid metabolism as a therapeutic vulnerability in neuroendocrine prostate cancer
PRJNA1254508 | ENA
GenomicsPIKFYVE Inhibition Mitigates Disease in Models of Diverse Forms of ALS [2]
PIKFYVE Inhibition Mitigates Disease in Models of Diverse Forms of ALS [2]
PRJNA912589 | ENA
GenomicsIdentification of PIKfyve kinase as a target in multiple myeloma
Identification of PIKfyve kinase as a target in multiple myeloma
PRJNA555832 | ENA
UnknownPIKfyve regulates melanosome biogenesis.
Not available
S-EPMC5889185 | biostudies-literature
GenomicsPIKFYVE Inhibition Mitigates Disease in Models of Diverse Forms of ALS [1]
PIKFYVE Inhibition Mitigates Disease in Models of Diverse Forms of ALS [1]
PRJNA912588 | ENA
ProteomicsA proximity interactome map of the VAC14-FIG4 complex using BioID
Conversion between phosphatidylinositol-3-phosphate and phosphatidylinositol-3,5-bisphosphate on endosomal membranes is critical for maturation of early endosomes to late endosomes/lysosomes, and is regulated by the PIKfyve-Vac14-Fig4 complex. In this study, we screened for the cellular interactome ...
ORGANISM(S): Homo sapiens (Human) 
2021-11-03 | PXD027917 | Pride
Ap-ms Vac14 Fig4 Protein-protein interactions Bioid Pikfyve Lc-ms/ms 
TranscriptomicsPIKfyve-regulated lipid metabolism as a therapeutic vulnerability in neuroendocrine prostate cancer
Neuroendocrine prostate cancer (NEPC) is a lethal, androgen receptor (AR)-independent subtype of prostate cancer that often arises after AR pathway inhibition and has limited treatment options. We hypothesized that NEPC might be susceptible to metabolic interventions targeting PIKfyve. Here, we iden...
ORGANISM(S): Homo sapiens 
2026-08-05 | GSE295392 | GEO
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