Sort   by:  
 Page size 
TranscriptomicsControlled release of exosomes by AMPK/SREBPs pathway
Exosome-like extracellular vesicles (EVs) are very important vesicles for intercellular signal transmission. Although host factors involving exosome-like EV production and release has been reported, the cellular signaling pathway regulating EV production is largely unknown. Here we performed a kinas...
ORGANISM(S): Homo sapiens 
2023-06-01 | GSE171807 | GEO
TranscriptomicsIdentification of PIKfyve kinase as a target in multiple myeloma
The cellular cytotoxicity of APY0201, a PIKfyve inhibitor, against multiple myeloma was initially identified in an unbiased in vitro chemical library screen. Activity was confirmed in all 25 cell lines tested and 40% of 100 ex vivo patient derived primary samples, and positively correlated with samp...
ORGANISM(S): Homo sapiens 
2019-09-19 | GSE134598 | GEO
UnknownIdentification of PIKfyve kinase as a target in multiple myeloma.
Not available
S-EPMC7271606 | biostudies-literature
GenomicsIdentification of PIKfyve kinase as a target in multiple myeloma
Identification of PIKfyve kinase as a target in multiple myeloma
PRJNA555832 | ENA
ProteomicsHydrogen Deuterium Exchange of PIKfyve construct with PI3P vesicles and inhibitors
We used HDXMS to study the confomational changes induced in a PIKfyve construct upon binding PI3P membrane and a variety of inhibitors. Here we showed a significant protection in deuterium exchange upon binding all inhibitors, and regions of protection and exposure upon binding PI3P membrane.
ORGANISM(S): Homo sapiens (Human) 
2025-10-15 | PXD044706 | Pride
Hdxms Apy0201 Ym-201636 Momipp Pikfyve Pi3p Apilimod 
GenomicsControlled release of exosomes by AMPK/SREBPs pathway
Controlled release of exosomes by AMPK/SREBPs pathway
PRJNA720942 | ENA
Sort   by:  
 Page size