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ProteomicsHighly-specific intracellular ubiquitination of a small molecule
Ubiquitin is a small, highly conserved protein that acts as a post-translational modification in eukaryotes. Ubiquitination of proteins frequently serves as a degradation signal, marking them for disposal by the proteasomal. Here, we report a novel small molecule from a diversity- oriented synthesis...
ORGANISM(S): Homo sapiens (Human) 
2026-04-06 | PXD053243 | Pride
Proteomics Degradation Ubiquitin 
ProteomicsProteomic and transcriptomic profiling reveal different aspects of aging in the kidney
The kidney is an excellent model for studying organ aging. Kidney function shows steady decline with age and is easy to assay using urine or blood samples. However, little is known about the molecular changes that take place in the kidney during the aging process. In order to better understand the m...
ORGANISM(S): Mus musculus (Mouse) 
2021-03-11 | PXD023823 | Pride
Kidney Qtl Proteomics Ageing 
ProteomicsDefining the effects of genetic variation on a proteome-wide scale
Genetic variation governs protein expression through both transcriptional and post-transcriptional processes. To investigate this relationship, we combined a multiplexed, mass spectrometry-based method for protein quantification with an emerging mouse model harboring extensive genetic variation fro...
ORGANISM(S): Mus musculus (Mouse) 
2016-06-15 | PXD002801 | Pride
Tmt Proteomics Quantitative Quantitative trait loci 
ProteomicsGenome-wide transcript and protein analysis reveals distinct features of aging in the mouse heart
Understanding the molecular mechanisms underlying age-related changes in the heart is challenging due to the contributions from numerous genetic and environmental factors. Genetically diverse outbred mice provide a model to study the genetic regulation of aging processes in healthy tissues from indi...
ORGANISM(S): Mus musculus (Mouse) 
2021-12-23 | PXD023724 | Pride
Heart Qtl Proteomics Ageing 
ProteomicsNon-coding divergence of the human X and Y chromosomes drove male-biased expression of dosage-sensitive regulators
Little is known about how Y-chromosome gene expression directly contributes to differences between XX (female) and XY (male) individuals in non-reproductive tissues. It is often said that Y-chromosome genes show low expression outside the testis. Here, we analyzed quantitative profiles of Y-chromoso...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD017055 | Pride
Tandem mass tags Proteomics Orbitrap lumos Lc-ms/ms 
ProteomicsA mass-tolerant database search identifies a large proportion of unassigned spectra in shotgun proteomics as modified peptides
Less than half of all MS/MS spectra acquired in shotgun proteomics typically result in a confident peptide match. Here we present an ultra-tolerant Sequest database search that allowed peptide matching even with modifications of unknown masses up to ±500 Da. From an HEK293 cell proteome-wide datase...
ORGANISM(S): Homo sapiens (Human) 
2015-06-03 | PXD001468 | Pride
Sequest Large scale Modifications Proteomics 
ProteomicsCdk1 controls global epigenetic landscape in embryonic stem cells
The cyclin-dependent kinase 1 (Cdk1) represents an ancient cell cycle kinase that has been conserved from yeast to humans. Cdk1 is the only essential mammalian Cdk, which drives cytokinesis by phosphorylating a large number of cellular proteins. To uncover additional functions of Cdk1, we generate...
ORGANISM(S): Mus musculus (Mouse) 
2020-10-05 | PXD015173 | Pride
Analogue sensivtive Cdk1 Proteomics Kinase 
ProteomicsA mass-tolerant database search identifies a large proportion of unassigned spectra in shotgun proteomics as modified peptides
Less than half of all MS/MS spectra acquired in shotgun proteomics typically result in a confident peptide match. Here we present an ultra-tolerant Sequest database search that allowed peptide matching even with modifications of unknown masses up to ±500 Da. From an HEK293 cell proteome-wide datas...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-06-19 | MSV000079841 | MassIVE
Proteomics,MultiomicsDefining the effects of genetic variation on a proteome-wide scale
Genetic variation governs protein expression through both transcriptional and post-transcriptional processes. To investigate this relationship, we combined a multiplexed, mass spectrometry-based method for protein quantification with an emerging mouse model harboring extensive genetic variation fro...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2017-11-08 | MSV000081696 | MassIVE
ProteomicsO.satival - Leaf, NSAF (Wuetal.,journalofproteomics2016)
abundance based on NSAF, Interaction consistency score: 7.5, Coverage: 4
ORGANISM(S): 39947 
2016-00-00 | 600882001 | PAXDB
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