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MetabolomicsElucidation of the epitranscriptomic RNA modification landscape of chikungunya virus

The genomes of positive-sense (+) single-stranded RNA (ssRNA) viruses are believed to be subjected to a wide range of RNA modifications. In this study, we focused on the chikungunya virus (CHIKV) as a model (+) ssRNA virus to study the landscape of viral RNA modification in infected human cells. ...

2024-06-11 | MTBLS8697 | MetaboLights
MetabolomicsVirus-induced codon-specific reprogramming to favor viral RNA translation
Recent evidence indicates that codon usage bias regulates gene expression. How viruses, such as the emerging mosquito-borne Chikungunya virus (CHIKV), express their genomes at high levels despite an enrichment in rare codons remains a puzzling question. Using ribosome footprinting, here we analysed ...
2025-06-16 | MTBLS2443 | MetaboLights
ProteomicsAedes aegypti Aag-2 cells proteome modulation in response to Chikungunya virus infection
Chikungunya virus (CHIKV) is a single-stranded positive RNA virus that belongs to the genus Alphavirus and is transmitted to humans by infected Aedes aegypti and Aedes albopictus bites. In humans, CHIKV can cause painful symptoms during acute and chronic stages of infection. However, the virus-vecto...
ORGANISM(S): Aedes aegypti Chikungunya virus strain S27-African prototype Insecta 
2022-06-02 | PXD033231 | Pride
Mosquito Rna helicases. Mass spectrometry Chikungunya virus Mitochondria Label-free quantification Apoptosis Protein synthesis 
ProteomicsAltered brain pathways following Chikungunya virus infection
A kinetic analysis of host proteome modifications in the brain of CHIKV-infected mice sampled before and after the onset of clinical symptoms was performed. The combination of 2D-DIGE and iTRAQ proteomic approaches, followed by mass spectrometry protein identification, revealed 177 significantly dif...
ORGANISM(S): Mus musculus (Mouse) 
2015-07-07 | PXD000736 | Pride
Brain Pathways modified Mouse Alphavirus Chikungunya virus Infection Itraq Pathogenesis 2d-dige 
ProteomicsDiscovery of Widespread Host Protein Interactions with the Pre-Replicated Genome of CHIKV using VIR-CLASP
The pioneer interactions between incoming viral RNA genomes and host proteins are crucial to infection and immune response. Until now, the ability to study these events was lacking. We developed VIR-CLASP (VIRal Cross-Linking And Solid-phase Purification) to characterize the earliest interactions be...
ORGANISM(S): Homo sapiens (Human) 
2020-05-11 | PXD015863 | Pride
Lc-ms/ms Virus 
GenomicsChikungunya virus
Genome sequencing of Chikungunya virus from the Americas
PRJNA294670 | ENA
ProteomicsTemporal quantitative proteomics of Chikungunya virus infected cells
To better understand the complex CHIKV-host interplay we used stable isotope labeling with amino acids in cell culture (SILAC) and LC-MS/MS to define the temporal dynamics of the cellular response to infection. Using samples harvested at 8, 10 and 12 hours post infection, over 4700 proteins were ide...
ORGANISM(S): Cercopithecidae (Old World monkeys) 
2015-03-16 | PXD001330 | Pride
Silac Chikungunya virus Quantitative proteomics Lc-msms 
ProteomicsGlobal proteome characterization of a three-dimensional human chondrocyte cell culture system during chikungunya virus (CHIKV) infection reveals distinct immune and inflammatory signatures
Chikungunya virus (CHIKV) belongs to alphavirus infections which often tend to deliberate musculoskeletal disorders affecting joints, muscles, and bones. Primary cells isolated from patients undergoing total knee replacement were utilized to perceive the effect of virus infection on it, upon isolati...
ORGANISM(S): Homo sapiens (Human) 
2025-10-06 | PXD055872 | Pride
2-dimension (2d) monolayer Chondrocytes Chikungunya virus (chikv) Proteomics 3-dimension (3d) spheroid cell culture 
GenomicsChikungunya virus
A field diagnosis and genotyping of chikungunya virus by a dried RT-LAMP and MinION sequencing
PRJDB7465 | ENA
GenomicsChikungunya virus strain:06-049
Chikungunya virus fidelity variant population diversity in Aedes aegypti mosquitoes
PRJNA541092 | ENA
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