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ProteomicsDiscovery of Widespread Host Protein Interactions with the Pre-Replicated Genome of CHIKV using VIR-CLASP
The pioneer interactions between incoming viral RNA genomes and host proteins are crucial to infection and immune response. Until now, the ability to study these events was lacking. We developed VIR-CLASP (VIRal Cross-Linking And Solid-phase Purification) to characterize the earliest interactions be...
ORGANISM(S): Homo sapiens (Human) 
2020-05-11 | PXD015863 | Pride
Lc-ms/ms Virus 
MetabolomicsVirus-induced codon-specific reprogramming to favor viral RNA translation
Recent evidence indicates that codon usage bias regulates gene expression. How viruses, such as the emerging mosquito-borne Chikungunya virus (CHIKV), express their genomes at high levels despite an enrichment in rare codons remains a puzzling question. Using ribosome footprinting, here we analysed ...
2025-06-16 | MTBLS2443 | MetaboLights
ProteomicsInteracting Partners of CHIKV nsP3 in Human Macrophages
Chikungunya virus (CHIKV), an alphavirus transmitted by mosquitoes, has instigated several epidemics in recent years, sparking intensive efforts to understand its biology. Despite progress, the understanding of CHIKV’s molecular interactions with host cell constituents, especially in susceptible cel...
ORGANISM(S): Homo sapiens (Human) 
2024-03-06 | PXD045252 | Pride
Virus host interaction Macrophages Nonstructural protein 3 Proteome Chikv 
ProteomicsGlobal proteome characterization of a three-dimensional human chondrocyte cell culture system during chikungunya virus (CHIKV) infection reveals distinct immune and inflammatory signatures
Chikungunya virus (CHIKV) belongs to alphavirus infections which often tend to deliberate musculoskeletal disorders affecting joints, muscles, and bones. Primary cells isolated from patients undergoing total knee replacement were utilized to perceive the effect of virus infection on it, upon isolati...
ORGANISM(S): Homo sapiens (Human) 
2025-10-06 | PXD055872 | Pride
2-dimension (2d) monolayer Chondrocytes Chikungunya virus (chikv) Proteomics 3-dimension (3d) spheroid cell culture 
ProteomicsAedes aegypti Aag-2 cells proteome modulation in response to Chikungunya virus infection
Chikungunya virus (CHIKV) is a single-stranded positive RNA virus that belongs to the genus Alphavirus and is transmitted to humans by infected Aedes aegypti and Aedes albopictus bites. In humans, CHIKV can cause painful symptoms during acute and chronic stages of infection. However, the virus-vecto...
ORGANISM(S): Aedes aegypti Chikungunya virus strain S27-African prototype Insecta 
2022-06-02 | PXD033231 | Pride
Mosquito Rna helicases. Mass spectrometry Chikungunya virus Mitochondria Label-free quantification Apoptosis Protein synthesis 
MetabolomicsElucidation of the epitranscriptomic RNA modification landscape of chikungunya virus

The genomes of positive-sense (+) single-stranded RNA (ssRNA) viruses are believed to be subjected to a wide range of RNA modifications. In this study, we focused on the chikungunya virus (CHIKV) as a model (+) ssRNA virus to study the landscape of viral RNA modification in infected human cells. ...

2024-06-11 | MTBLS8697 | MetaboLights
TranscriptomicsContrasted transcriptomic responses to a rhabdovirus and a togavirus in zebrafish embryo
Characterization of the zebrafish embryonic host response to viral infection (CHIKV, IHNV) by means of global expression analysis Three sets of larvae infected by CHIKV or IHNV were analyzed (2 color hybridizations against control sets of larvae)
ORGANISM(S): Danio rerio 
2014-05-17 | E-GEOD-47057 | biostudies-arrayexpress
GenomicsThe transcriptomic landscape of multiple organs in CHIKV-infected Rhesus monkeys and mice
The transcriptomic landscape of multiple organs in CHIKV-infected Rhesus monkeys and mice
PRJNA1091580 | ENA
GenomicsN6-methyladenosine modification is not a general trait of viral RNA genomes [CHIKV]
N6-methyladenosine modification is not a general trait of viral RNA genomes [CHIKV]
PRJNA967595 | ENA
GenomicsChikungunya virus
ARUBA CHIKV
PRJDB8750 | ENA
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