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TranscriptomicsSingle cell sequencing data of developing human intestine tissue and human and chimpanzee intestine organoids
To study the species difference in developing intestine between human and chimpanzees, we performed scMultiome profiling on developing human intestine tissues and matched intestinal epithelial only organoids (also known as enteroids), and performed scRNA-seq and scATAC-seq measurements on human and ...
ORGANISM(S): Pan troglodytes 
2025-08-08 | E-MTAB-15112 | biostudies-arrayexpress
TranscriptomicsFLASH-seq of human and chimpanzee single spheroid budding at different time points
We utilized FLASH-seq, a full-length bulk RNA sequencing method, to sequence single spheroids in a 96-well format by manually sorting human and chimpanzee spheroids budding at day 3 to day 6 of midgut/hindgut patterning. We would like to use this data to assess the early stages of differentiation an...
ORGANISM(S): Homo sapiens 
2025-08-08 | E-MTAB-15107 | biostudies-arrayexpress
TranscriptomicsModeling human brain evolution using induced pluripotent stem cells: comparative analysis of neuronal development in humans and chimpanzees
Understanding evolutionary mechanisms underlying expansion and reorganization of the human brain represents an important aspect in analyzing the emergence of cognitive abilities typical of our species. Comparative analyses of neuronal phenotypes in closest living relatives (Pan troglodytes; the comm...
ORGANISM(S): Pan troglodytes 
2016-08-07 | E-GEOD-83638 | biostudies-arrayexpress
TranscriptomicsExtensive Evolutionary Changes in Regulatory Element Activity during Human Origins Are Associated with Altered Gene Expression and Positive Selection [DGE-seq]
The human genome shares a remarkable amount of genomic sequence with our closest living primate relatives. Researchers have long sought to understand what regions of the genome are responsible for unique species-specific traits. Previous studies have shown that many genes are differentially expresse...
ORGANISM(S): Homo sapiens 
2014-02-13 | E-GEOD-54906 | biostudies-arrayexpress
TranscriptomicsPathogenesis of hepatitis E and hepatitis C in chimpanzees: Similarities and differences
The chimpanzee is the only model other than man for investigating the pathogenesis of viral hepatitis types A through E. Studies of the host response, including microarray analyses, have relied on the close relationship between these two primate species: chimpanzee samples are commonly tested with h...
ORGANISM(S): Pan troglodytes 
2010-09-21 | E-GEOD-22160 | biostudies-arrayexpress
TranscriptomicsMethylation profiling of the chimpanzee CNTNAP2 gene in brain using high-resolution tiling arrays.
Accelerated brain development is a unique feature of the human species. Not only the size but also morphology, in particular the connections between frontal cortex and basal ganglia distinguish the human brain from great apes and other primates. Recent findings suggest that structural features which...
ORGANISM(S): Pan troglodytes 
2014-02-20 | E-GEOD-52949 | biostudies-arrayexpress
GenomicsEvolutionary Significance of DNA Methylation in Human and Chimpanzee Brains
We compared the genome-wide patterns of DNA methylation in the brains of humans to those of our closest evolutionary relative, chimpanzees, using base-pair resolution whole-genome methylation maps of the prefrontal cortex. Our data reveal that the prefrontal cortex is the most heavily methylated am...
ORGANISM(S): Human 
2012-09-04 | E-GEOD-37202 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse livers from animals fed four different diets
Beyond the DNA sequence difference between humans and closely related apes, there are large differences in the environments that these species experience. One prominent example for this is diet. The human diet diverges from those of other primates in various aspects, such as having a high calorie an...
ORGANISM(S): Mus musculus 
2009-04-08 | E-GEOD-6297 | biostudies-arrayexpress
TranscriptomicssnRNA-seq of chimpanzee (Pan troglodytes) adult testis
Single-nucleus RNA sequencing (snRNA-seq) was used to profile the transcriptome of 12,352 nuclei in chimpanzee adult testis. This dataset includes three samples from three different individuals. This dataset is part of a larger evolutionary study of adult testis at the single-nucleus level (97,521 s...
ORGANISM(S): Pan troglodytes 
2021-11-08 | E-MTAB-11064 | biostudies-arrayexpress
ProteomicsCross-species multi-omic analyses of great ape ejaculates reveal novel strategies for enhancing sperm cryopreservation in Bornean orangutan (Pongo pygmaeus)
The orangutan (Pongo spp., Linnaeus, 1760) is the most endangered great ape, classified as critically endangered. Sperm cryopreservation is a valuable tool for banking genetic resources and solving the complexities of relocating animals; however, cryopreservation protocols remain suboptimal for this...
ORGANISM(S): Pan troglodytes (Chimpanzee) Pongo pygmaeus (Bornean orangutan) 
2026-03-08 | PXD073407 | Pride
Chimpanzee Orangutan Seminal plasma Sperm Ejaculate 
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