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ProteomicsRewiring oncogenic transcriptional complexes with Domain-ALTerAtion Chimeras (DALTACs) in prostate cancer
Transcriptional addiction to the androgen receptor (AR) underlies metastatic castration-resistant prostate cancer (mCRPC)1, where AR maintains oncogenic programs through domain-specific interactions with the acetyltransferases p300/CBP2. Here, we describe a distinct therapeutic modality, Domain-ALTe...
ORGANISM(S): Homo sapiens (Human) 
2026-10-30 | PXD084247 | Pride
Daltac ar-p300/cbp prostate cancer 
ProteomicsA Stress-Adaptive Lipid Kinase Axis Defines Metabolic Vulnerabilities in Neuroendocrine Prostate Cancer
Neuroendocrine prostate cancer (NEPC) persists in a profoundly hypoxic microenvironment, yet the mechanisms enabling tumor adaptation to this metabolically challenging niche remain undefined. Here, we identify the lipid kinase PIKfyve as overexpressed in NEPC, functioning as a central node in a stre...
ORGANISM(S): Homo sapiens (Human) 
2026-09-14 | PXD076640 | Pride
UnknownIntegration of Germline Pharmacogenetics Into a Tumor Sequencing Program.
Not available
S-EPMC7434089 | biostudies-literature
ProteomicsTargeting histone H2B acetylated enhanceosomes via p300/CBP degradation in prostate cancer
Prostate cancer is driven by oncogenic transcription factor enhanceosomes comprising chromatin and epigenetic regulators. The lysine acetyltransferases p300 and CBP are key cofactors that activate enhancers through histone acetylation. Here, we identify p300/CBP-mediated multisite acetylation of the...
ORGANISM(S): Homo sapiens (Human) 
2025-07-28 | PXD065228 | Pride
Prostate cancer Protac degrader cbpd-409 P300/cbp 
TranscriptomicsChimeraScan: A tool for identifying chimeric transcription in sequencing data
Next Generation Sequencing technologies have enabled de novo gene fusion discovery that could reveal candidates with therapeutic significance in cancer. Here we present an open-source software package, ChimeraScan, for the discovery of chimeric transcription between two independent transcripts. Thre...
ORGANISM(S): Homo sapiens 
2011-09-01 | E-GEOD-29098 | biostudies-arrayexpress
GenomicsChIP-Seq analysis of ER binding sites in MCF7 breast cancer cells
Estrogen Receptor (ER) is a hormonal transcription factor that plays important roles in breast cancer. It functions primarily through binding to the regulatory regions of target genes containing the consensus ERE motifs. In order to identify ER target genes and re-define the ERE motifs we performed...
ORGANISM(S): Homo sapiens 
2010-02-01 | E-GEOD-19013 | biostudies-arrayexpress
TranscriptomicsTranscriptome sequencing across a prostate cancer cohort identifies PCAT-1, an unannotated lincRNA implicated in disease progression (RNA-Seq data)
Noncoding RNAs (ncRNAs) are emerging as key molecules in human cancer, with the potential to serve as novel markers of disease and to reveal uncharacterized aspects of tumor biology. Here we discover 121 unannotated prostate cancerM-bM-^@M-^Sassociated ncRNA transcripts (PCATs) by ab initio assembly...
ORGANISM(S): Homo sapiens 
2011-08-02 | E-GEOD-25183 | biostudies-arrayexpress
TranscriptomicsIntegrative Molecular Concepts Modeling of Prostate Cancer Progression
Using laser capture microdissection to isolate over 100 specific cell populations, we report the profiling of prostate cancer progression from benign epithelium to metastatic disease. By analyzing these expression signatures in the context of over 15,000 â??molecular conceptsâ??, or sets of biologic...
ORGANISM(S): Homo sapiens 
2010-06-05 | E-GEOD-6099 | biostudies-arrayexpress
ProteomicsRewiring Oncogenic Transcriptional Complexes with Domain-ALTerAtion Chimeras (DALTACs) in Prostate Cancer
Transcriptional addiction to the androgen receptor (AR) underlies metastatic castration-resistant prostate cancer (mCRPC)1, where AR maintains oncogenic programs through domain-specific interactions with the acetyltransferases p300/CBP2. Here, we describe a distinct therapeutic modality, Domain-ALTe...
ORGANISM(S): Homo sapiens (Human) 
2026-10-30 | PXD084305 | Pride
Ar Prostate cancer P300/cbp Daltac 
ProteomicsRewiring oncogenic transcriptional complexes with domain-alteration chimeras (DALTACs) in prostate cancer
Transcriptional addiction to the androgen receptor (AR) underlies metastatic castration-resistant prostate cancer (mCRPC)1, where AR maintains oncogenic programs through domain-specific interactions with the acetyltransferases p300/CBP2. Here, we describe a distinct therapeutic modality, Domain-ALTe...
ORGANISM(S): Homo sapiens (Human) 
2026-10-30 | PXD084250 | Pride
Ar Prostate cancer P300 Daltac 
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