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TranscriptomicsTranscription profiling of human common melanocytic nevi, radial and vertical growth phase melanomas, melanoma metastases and dysplastic nevi
Despite malignant cutaneous melanoma is relatively rare compared to other skin cancers, it is still responsible for 80% of all skin cancer-related deaths. To identify molecular signatures of melanoma progression, excisional biopsies from 18 common melanocytic nevi (CMN), 8 primary radial growth phas...
ORGANISM(S): Homo sapiens 
2009-10-10 | E-GEOD-12391 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse primary keratinocytes expressing Rho/CRIK to study the impact of Rho signaling pathway on gene expression.
Rho GTPases integrate control of cell structure and adhesion with downstream signaling events. In keratinocytes, RhoA is activated at early times of differentiation and plays an essential function in establishment of cell–cell adhesion. We report here that, surprisingly, Rho signaling suppresses dow...
ORGANISM(S): Mus musculus 
2007-09-07 | E-GEOD-3162 | biostudies-arrayexpress
TranscriptomicsAnalysis of ETS gene expression patterns uncovers novel ETS mediated gene silencing pathways in prostate cancers
Deregulated expression of ETS transcription factors with oncogenic and tumor suppressor function occurs frequently in prostate cancer leading to profound alterations of the cancer transcriptome. By integrating genomic and functional studies we identified key targets of the aberrantly expressed ETS ...
ORGANISM(S): Homo sapiens 
2010-06-09 | E-GEOD-14206 | biostudies-arrayexpress
TranscriptomicsA platform of patient-derived tumor xenografts (EOC-xenografts) to recapitulate the clinicopathology and genetic alterations of ovarian cancer
Epithelial ovarian cancer (EOC) is the most lethal gynecological malignancy. On the basis of its histopathology and molecular-genomic changes ovarian cancer has been divided into subtypes, each with distinct biology and outcome. The aim of this study was to develop a panel of patient-derived EOC-xen...
ORGANISM(S): Homo sapiens 
2015-01-07 | E-GEOD-56920 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse keratinocytes in embryos and newborns, and Notch1 expression in newborns
Comparison between pattern of gene expression in uncultured keratinocytes derived from the epidermis of embryonic mice (E15.5) versus newborn mice and comparison between pattern of gene expression in primary keratinocytes derived from newborn mice plus/minus activated Notch1 expression.
ORGANISM(S): Mus musculus 
2008-06-11 | E-GEOD-1569 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human and mouse keratinocytes infected with AD and Ad-NotchIC viruses reveals cross-regulation between Notch and p63 in keratinocyte commitment to differentiation
Notch signaling promotes commitment of keratinocytes to differentiation and suppresses tumorigenesis. p63, a p53 family member, has been implicated in establishment of the keratinocyte cell fate and/or maintenance of epithelial self-renewal. Here we show that p63 expression is suppressed by Notch1 a...
ORGANISM(S): Mus musculus 
2008-06-13 | E-GEOD-5229 | biostudies-arrayexpress
TranscriptomicsThe network of genes regulated by Ago1 in metastatic prostate cancer PC3
The objective of this study was to evaluate the consequences of Ago1 knockdown in metastatic prostate cancer cells PC3. To this end we profiled RNA from PC3 cells 72 hours following the transfection with a scramble siRNA (siGL3) and a siRNA targeting Ago1 (siAgo1). We profiled RNA from PC3 cells 72 ...
ORGANISM(S): Homo sapiens 
2015-05-22 | E-GEOD-57885 | biostudies-arrayexpress
TranscriptomicsComparison Between Gene Expression Profiles of Sensitive and Resistant Trabectedin Liposarcoma Cell Lines
Gene expression profiles of 402-91 FUS-CHOP type I cells have been compared to 402-91/ET cells made resistant to Trabectedin Experiments were performed on purified RNA from independent batches of 402-91 and 402-91/ET cells without drug treatment.
ORGANISM(S): Homo sapiens 
2010-07-13 | E-GEOD-20350 | biostudies-arrayexpress
TranscriptomicsApoptosis, autophagy and senescence protect BRAFV600E nevi from malignant transformation
The oncogenic mutation BRAFV600E is a common event in nevi and melanomas, which are aggressive skin tumors characterized by MAPK signaling pathway activation. It has been observed that mutated benign melanocytic lesions can remain unchanged for decades, but also proliferate or undergo oncogene-ind...
ORGANISM(S): Homo sapiens 
2016-06-30 | E-GEOD-23976 | biostudies-arrayexpress
TranscriptomicsOverexpression of CD157 contributes to epithelial ovarian cancer progression by promoting mesenchymal differentiation.
Epithelial ovarian carcinoma (EOC) is an aggressive tumor often diagnosed at an advanced stage, when there is little prospect for cure. Despite some advances in surgical and chemotherapeutic strategies, only marginal improvements in patient outcome have been obtained. Hence, understanding the biolog...
ORGANISM(S): Homo sapiens 
2012-12-31 | E-GEOD-36364 | biostudies-arrayexpress
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