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ProteomicsIdentification of β-Catenin-Interacting Proteins in Nuclei of Aquaporin-2-Expressing Rat Collecting Duct Cells
The gene encoding the aquaporin-2 water channel is regulated transcriptionally in response to vasopressin. In the renal collecting duct, vasopressin stimulates the nuclear translocation and phosphorylation (at Ser552) of β-catenin, a multifunctional protein that can act as a transcriptional co-regul...
ORGANISM(S): Rattus norvegicus (Rat) 
2018-10-26 | PXD005792 | Pride
Transcription Transcriptional co-regulator Aquaporin-2 Kidney 
ProteomicsSerine/threonine phosphatases and aquaporin-2 regulation in renal collecting duct
Phosphorylation of the aquaporin-2 (AQP2) water channel at four COOH-terminal serines plays a central role in the regulation of water permeability of the renal collecting duct. The level of phosphorylation at these sites is determined by a balance between phosphorylation by protein kinases and depho...
ORGANISM(S): Rattus norvegicus (Rat) 
2018-10-26 | PXD005488 | Pride
Systems biology  collecting duct  kidney  vasopressin  lc-ms/ms 
ProteomicsEpidermal Growth Factor-Induced Protein Phosphorylation Changes in Rat Inner Medullary Collecting Duct
Epidermal growth factor (EGF) is a potent mitogenic agent promoting cell differentiation, proliferation, and growth. The kidney thick ascending limb of Henle’s loop and distal convoluted tubule were identified as major sites of EGF synthesis. As expected, EGF can modulate the functioning of kidney...
ORGANISM(S): Rattus norvegicus (Rat) 
2025-06-26 | PXD017192 | Pride
Water Mass spectrometry Vasopressin Kidney Mapk Protein kinase Erbb 
ProteomicsIdentification of the UT-A1 Urea Channel Interactome
The urea channel Slc14a2 (or UT-A1) mediates vasopressin-regulated urea transport across the inner medullary collecting duct (IMCD). Previously, UT-A1 was found to present in a high molecular weight complex, suggesting UT-A1 is involved in certain protein-protein interactions. The present study so...
ORGANISM(S): Rattus norvegicus (Rat) 
2019-11-08 | PXD003496 | Pride
Asopressin Kidney. Mass spectrometry Interacting protein Protein kinase Stoichiometry 
ProteomicsComprehensive Proteomic Profiling of Nuclear Fractions from Native Renal Inner Medullary Collecting Duct Cells
Regulation of renal water excretion is dependent on control of the molecular water channel aquaporin‐2 by the peptide hormone vasopressin in renal collecting duct cells. The control is in part due to the regulation of transcription of the Aqp2 gene and other genes by vasopressin. A systems biology‐b...
ORGANISM(S): Rattus norvegicus (Rat) 
2018-10-24 | PXD002680 | Pride
Transcription Transcription factor Kidney Lc‐ms/ms Chromatin Mrna splicing 
UnknownBronchoscopic debulking for endobronchial malignancy: Predictors of recanalization and recurrence.
Not available
S-EPMC4632924 | biostudies-literature
UnknownDiagnosis of tuberculosis pleurisy with three endoscopic features via pleuroscopy.
Not available
S-EPMC7874337 | biostudies-literature
UnknownBrain metastases in patients with non-small cell lung cancer: the role of mutated-EGFRs with an exon 19 deletion or L858R point mutation in cancer cell dissemination.
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S-EPMC5581119 | biostudies-literature
UnknownComparative survival analysis of platinum-based adjuvant chemotherapy for early-stage squamous cell carcinoma and adenocarcinoma of the lung.
Not available
S-EPMC9119352 | biostudies-literature
UnknownThe potential impact of sleep-related movement disorders on stroke risk: a population-based longitudinal study.
Not available
S-EPMC5914305 | biostudies-literature
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