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TranscriptomicsMCT1 modulates cancer cell pyruvate export and growth of tumors that co-express MCT1 and MCT4
Many cancers rely on glycolytic metabolism to fuel rapid proliferation. This has spurred interest in designing drugs that target tumor glycolysis such as AZD3965, a small molecule inhibitor of Monocarboxylate Transporter 1 (MCT1) currently undergoing Phase I evaluation for cancer treatment. Since ...
ORGANISM(S): Homo sapiens 
2016-03-08 | E-GEOD-76675 | biostudies-arrayexpress
Unknown2-Hydroxyglutarate Inhibits ATP Synthase and mTOR Signaling.
Not available
S-EPMC4663076 | biostudies-literature
ProteomicsmTORC2 regulates amino acid metabolism in cancer by phosphorylation of the cystine-glutamate antiporter xCT
Mutations in cancer reprogram amino acid metabolism to drive tumor growth, but the molecular mechanisms are not well understood. Using an unbiased proteomic screen, we identified mTORC2 as a critical regulator of amino acid metabolism in cancer via phosphorylation of the cystine-glutamate antiporter...
ORGANISM(S): Homo sapiens (Human) 
2017-06-28 | PXD006461 | Pride
Mtorc2 Xct 
UnknownRecurrent patterns of DNA copy number alterations in tumors reflect metabolic selection pressures.
Not available
S-EPMC5327725 | biostudies-literature
MetabolomicsArginine starvation kills tumor cells through aspartate exhaustion and mitochondrial dysfunction
Defective arginine synthesis, due to the silencing of argininosuccinate synthase 1 (ASS1), is a common metabolic vulnerability in cancer, known as arginine auxotrophy. Understanding how arginine depletion kills arginine-auxotrophic cancer cells will facilitate the development of anti-cancer therapeu...
2019-11-07 | MTBLS745 | MetaboLights
UnknownControl of intestinal stem cell function and proliferation by mitochondrial pyruvate metabolism.
Not available
S-EPMC6137334 | biostudies-literature
UnknownMYC is a regulator of androgen receptor inhibition-induced metabolic requirements in prostate cancer.
Not available
S-EPMC11972006 | biostudies-literature
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