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TranscriptomicsANGUSTIFOLIA 3 binds SWI/SNF chromatin remodeling complexes to regulate transcription during Arabidopsis leaf development
The transcriptional coactivator ANGUSTIFOLIA 3 (AN3) stimulates cell proliferation during Arabidopsis leaf development, but the molecular mechanism is largely unknown. We show here that inducible nuclear localization of AN3 during initial leaf growth results in differential expression of important t...
ORGANISM(S): Arabidopsis thaliana 
2014-09-09 | E-GEOD-42875 | biostudies-arrayexpress
TranscriptomicsInvolvement of a chromatin remodeling complex in damage tolerance during DNA replication
ATP-dependent chromatin remodeling complexes have been shown to participate in DNA replication in addition to transcription and DNA repair. However, the mechanisms of their involvement in DNA replication remain unclear. Here, we reveal a specific function of the yeast INO80 chromatin remodeling comp...
ORGANISM(S): Saccharomyces cerevisiae 
2010-06-20 | E-GEOD-18570 | biostudies-arrayexpress
GenomicsGenome-wide profile of the SWI/SNF chromatin remodeling complex
A systems understanding of nuclear organization and events is critical for determining how cells divide, differentiate and respond to stimuli and for identifying the causes of diseases. Chromatin remodeling complexes such as SWI/SNF have been implicated in a wide variety of cellular processes includ...
ORGANISM(S): Homo sapiens 
2011-01-10 | E-GEOD-24397 | biostudies-arrayexpress
TranscriptomicsGenome-wide localization of Ino80 and Arp5 on chromosome in Saccharomyces cerevisiae
Background: Chromatin remodeling complexes facilitate the access of enzymes that mediate transcription, replication or repair of DNA by modulating nucleosome position and/or composition. Ino80 is the DNA-dependent Snf2-like ATPase subunit of a complex whose nucleosome remodeling activity requires ac...
ORGANISM(S): Saccharomyces cerevisiae 
2008-04-10 | E-GEOD-9233 | biostudies-arrayexpress
TranscriptomicsIno80 chromatin remodeling complex promotes recovery of stalled replication forks
This SuperSeries is composed of the following subset Series: GSE9233: Genome-wide localization of Ino80 and Arp5 on chromosome in Saccharomyces cerevisiae GSE9420: Genome-wide localization of Ino80 on chromosome in Saccharomyces cerevisiae Keywords: SuperSeries Refer to individual Series
ORGANISM(S): Saccharomyces cerevisiae 
2008-04-10 | E-GEOD-9421 | biostudies-arrayexpress
TranscriptomicsA SWI/SNF nucleosome remodeling complex acts in non-coding RNA-mediated transcriptional silencing
RNA-mediated transcriptional silencing prevents deleterious effects of transposon activity and controls the expression of protein-coding genes. It involves long non-coding RNAs (lncRNAs)1, which in Arabidopsis thaliana are produced by a specialized RNA Polymerase V (Pol V)2. lncRNAs guide Argonaute-...
ORGANISM(S): Arabidopsis thaliana 
2012-12-01 | E-GEOD-38400 | biostudies-arrayexpress
TranscriptomicsGenome-wide localization of Ino80 on chromosome in Saccharomyces cerevisiae
Background: Chromatin remodeling complexes facilitate the access of enzymes that mediate transcription, replication or repair of DNA by modulating nucleosome position and/or composition. Ino80 is the DNA-dependent Snf2-like ATPase subunit of a complex whose nucleosome remodeling activity requires ac...
ORGANISM(S): Saccharomyces cerevisiae 
2008-04-10 | E-GEOD-9420 | biostudies-arrayexpress
ProteomicsNPM and NPM-MLF1 interact with chromatin remodeling complexes and influence their recruitment to specific genes
Nucleophosmin (NPM1) is either frequently mutated or subjected to chromosomal translocation in acute myeloid leukemia (AML). NPM protein is primarily located in the nucleus, but the recurrent NPMc+ mutation is characterized by cytoplasmic localization and leukemogenic properties. Similarly, the NPM-...
ORGANISM(S): Homo sapiens (Human) 
2019-10-18 | PXD012305 | Pride
Chromatin remodeling complexes Npm-mlf1 Leukemia Npm Proteomic Epigenetic 
ProteomicsA non-canonical BRD9-containing BAF chromatin remodeling complex regulates naïve pluripotency in mouse embryonic stem cells
The mammalian BRG1-associated factors (BAF) complex is a multi-subunit chromatin remodeling complex that is an important component of the embryonic stem cell (ESC) transcriptional regulatory network. However, the role of individual subunits in BAF complex targeting and function needs to be elucidate...
ORGANISM(S): Mus musculus (Mouse) 
2018-10-18 | PXD010670 | Pride
Baf Chromatin remodeling 
GenomicsGenomic analyses of gynecologic carcinosarcomas reveal frequent mutations in chromatin remodeling genes
Malignant Mixed Müllerian Tumors, also known as carcinosarcomas, are rare tumors of gynecological origin. Here we perform whole exome analyses of 22 tumors using massively parallel sequencing to determine the mutational landscape of this tumor type. On average, we identify 43 mutations per tumor, ...
EGAS00001000941 | EGA
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