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MetabolomicsMicrobiota-indole-3-propionic acid-heart axis mediates the protection of leflunomide against αPD1-induced cardiotoxicity in mice
Anti-programmed death 1 (αPD1) immune checkpoint blockade is used in combination for cancer treatment but associated with cardiovascular toxicity. Finding drugs that suppress cardiovascular toxicity but not compromise the efficacy of αPD1-mediated immunotherapy is of great importance. Leflunomide (L...
2025-03-12 | MTBLS12066 | MetaboLights
ProteomicsUbiquitome profiling uncovers disturbed mitochondrial remodeling as an outcome of doxorubicin-induced cardiotoxicity in old mice
The urgent need to understand the molecular modulation associated with chronic cardiotoxicity of doxorubicin (DOX) has prompted us to investigate the ubiquitome profile of aged cardiac muscle. Using old CD-1 male mice administered with a DOX dosage established to induce cardiotoxicity, we performed ...
ORGANISM(S): Mus musculus (Mouse) 
2025-06-30 | PXD048078 | Pride
Mitochondrial dynamics Old Chronic cardiotoxicity Ubiquitination Anticancer therapy Cardio-oncology 
TranscriptomicsMicroRNA array profiling on human pluripotent stem cell-derived cardiomyocytes exposed to doxorubicin
Cardiomyocytes derived from human pluripotent stem cells were exposed to the cardiotoxic drug Doxorubicin in order to assess the utility of this cell system as a model for drug-induced cardiotoxicity. Cells are exposed to different concentrations of doxorubicin for up to 48 hours followed by a 12 da...
ORGANISM(S): Homo sapiens 
2017-10-28 | E-MTAB-6052 | biostudies-arrayexpress
ProteomicsTotal protein profiles of human induced pluripotent stem cell-derived cardiomyocytes in response to four tyrosine kinase inhibitors
Drug-induced cardiotoxicity is a widespread clinical issue affecting numerous drug classes and remains difficult to treat. One such drug class is Tyrosine Kinase Inhibitors (TKIs), which cause varying degrees of contraction-related cardiotoxicity usually after weeks of exposure. Understanding molecu...
ORGANISM(S): Homo sapiens (Human) 
2019-05-16 | PXD012043 | Pride
Tyrosine kinase inhibitor Cardiotoxicity Aerobic glycolysis Human induced pluripotent stem cell-derived cardiomyocyte Mitochondrial respiration Drug adaptation Tandem mass tag mass spectrometry 
UnknownIdentification of novel biomarkers involved in doxorubicin-induced acute and chronic cardiotoxicity, respectively, by integrated bioinformatics.
Not available
S-EPMC9874088 | biostudies-literature
UnknownA Biophysical Systems Approach to Identifying the Pathways of Acute and Chronic Doxorubicin Mitochondrial Cardiotoxicity.
Not available
S-EPMC5117565 | biostudies-literature
UnknownSchisandrin B prevents doxorubicin-induced chronic cardiotoxicity and enhances its anticancer activity in vivo.
Not available
S-EPMC3229562 | biostudies-literature
GenomicsPanax notoginseng -derived extracellular vesicles alleviate doxorubicin-induced cardiotoxicity by suppressing p53 activation
Panax notoginseng -derived extracellular vesicles alleviate doxorubicin-induced cardiotoxicity by suppressing p53 activation
PRJNA1463682 | ENA
UnknownInvestigation of the Antiremodeling Effects of Losartan, Mirabegron and Their Combination on the Development of Doxorubicin-Induced Chronic Cardiotoxicity in a Rat Model.
Not available
S-EPMC8877618 | biostudies-literature
ProteomicsMethodological aspects of µLC-MS/MS for wide-scale proteomic analysis of anthracycline-induced cardiomyopathy
The effort to utilize microflow liquid chromatography for deep-scale proteomic analysis (µLC-MS/MS) is still growing. In this work, we utilized two-dimensional LC separation and peptide derivatization by tandem mass tag and assessed the capability of µLC-MS/MS to reveal protein changes associated wi...
ORGANISM(S): Oryctolagus cuniculus (Rabbit) 
2025-04-30 | PXD047014 | Pride
Cardiotoxicity Tmt 2d-separation Microlc-ms/ms Daunorubicin 
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