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TranscriptomicsTemporal effects of intermittent- and sustained hypoxia on gene expression patterns in rat lungs
Time-course gene expression profiles were obtained from lung tissues of the rats treated with room air, intermittent- (IH) or sustained hypoxia (SH) for 1, 3, 7, 14 and 30 days using CodeLink microarrays. Using a systems biology approach, we observed that two different mechanisms are involved in the...
ORGANISM(S): Rattus norvegicus 
2008-12-17 | E-GEOD-8705 | biostudies-arrayexpress
ProteomicsIn-depth Proteomics and Phosphoproteomics Reveal Biomarkers and Molecular Pathways of Chronic Intermittent Hypoxia in Mice
Obstructive sleep apnea (OSA) syndrome is characterized by Chronic Intermittent Hypoxia (CIH). In this study, we employed Data-independent acquisition (DIA) Mass Spectrometry to conduct comprehensive proteomic and phosphoproteomic profiling of a murine model subjected to Chronic Intermittent Hypoxia...
ORGANISM(S): Homo Sapiens 
PXD053746 |
TranscriptomicsDistinct Mechanisms Underlying Tolerance to Intermittent and Constant Hypoxia in Drosophila melanogaster
Background: Constant hypoxia (CH) and intermittent hypoxia (IH) occur during several pathological conditions such as asthma and obstructive sleep apnea. Our research is focused on understanding the molecular mechanisms that lead to injury or adaptation to hypoxic stress using Drosophila as a model ...
ORGANISM(S): Drosophila melanogaster 
2009-04-30 | E-GEOD-14981 | biostudies-arrayexpress
TranscriptomicsGene expression and phenotypic characterization of mouse heart after chronic constant or intermittent hypoxia
Chronic constant hypoxia (CCH), such as in pulmonary diseases or high altitude, and chronic intermittent hypoxia (CIH), such as in sleep apnea, can lead to major changes in the heart. The molecular mechanisms underlying these cardiac alterations are not well understood. We hypothesized that analysis...
ORGANISM(S): Mus musculus 
2010-06-10 | E-GEOD-2271 | biostudies-arrayexpress
TranscriptomicsChronic Intermittent Hypoxia Increases Alveolar Surface Area in Adult Mice
Obstructive sleep apnea (OSA) leads to increased cardiovascular morbidity and mortality, which have been attributed to intermittent hypoxia (IH). The effects of IH on lung structure and function are unknown. We used a mouse model of chronic IH, which mimics the O2 profile in patients with OSA. We ex...
ORGANISM(S): Mus musculus 
2010-12-31 | E-GEOD-21409 | biostudies-arrayexpress
TranscriptomicsGene Expression Profile in Developing Mouse Brain Following Chronic Hypoxia Treatment
In this study, we determined the effect of chronic consistent hypoxia (CCH) and chronic intermittent hypoxia (CIH) on global gene expression in cortical and hippocampal region of developing mouse brain using long-oligo beadschip arrays. Keywords: Gene expression profile Control-Cortex: Cortical samp...
ORGANISM(S): Mus musculus 
2010-06-25 | E-GEOD-8262 | biostudies-arrayexpress
ProteomicsCharacterization of lysine acetylome in mice subjected to chronic intermittent hypoxia
Chronic intermittent hypoxia (CIH) can negatively affect hippocampal function through various molecular mechanisms. Protein acetylation, a frequently occurring modification, plays crucial roles in synaptic plasticity and cognitive processes. However, the global protein acetylation induced by CIH in ...
ORGANISM(S): Mus Musculus 
2024-02-07 | PXD049226 |
TranscriptomicsTranscription profiling of mouse liver to identify the effect of intermittent hypoxia on gene expression in the liver of ob/ob mice
All animals were kept in a controlled environment (22-24 °C with a 12 h : 12 h light : dark cycle; lights on at 09.00) on a standard chow diet with free access to water. Five ob/ob mice (sample_ids GSM32865-GSM32869) were placed in the intermittent hypoxia (IH) chamber and subjected to IH for 12 con...
ORGANISM(S): Mus musculus 
2007-11-01 | E-GEOD-1873 | biostudies-arrayexpress
ProteomicsAcetylome analyses provide new insights into the effect of chronic intermittent hypoxia on hypothalamus-dependent endocrine metabolism impairment
Background: Paediatric obstructive sleep apnoea (OSA) is a highly prevalent sleep disorder resulting in chronic intermittent hypoxia (CIH) that has been linked to metabolism and endocrine impairment. Protein acetylation, which is a frequently occurring posttranslational modification, plays pivotal r...
ORGANISM(S): Mus musculus (Mouse) 
2024-10-17 | PXD051767 | Pride
Lysine acetylation Paediatric obstructive sleep apnoea (osa). Endocrine metabolism Chronic intermittent hypoxia Hypothalamus 
ProteomicsChanges in the hippocampal proteome of chronic intermittent hypoxia mice
Cognitive and behavioural scales have indicated chronic intermittent hypoxia (CIH)-induced abnormalities in learning, memory, and cognition . Although earlier studies have shown that CIH impacts adult hippocampal neurogenesis and cognitive processes, the exact mechanism through which CIH affects hip...
ORGANISM(S): Mus Musculus 
2024-02-07 | PXD049225 |
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