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MetabolomicsDisturbed Microbiota-Metabolites-Immune Interaction Network is Associated with Olfactory Dysfunction in Patients with Chronic Rhinosinusitis

PURPOSE: Olfactory dysfunction (OD) is a debilitating symptom frequently reported by patients with chronic rhinosinusitis (CRS) and it is associated with a dysregulated sinonasal inflammation. However, little information is available about the effect of the inflammation-related n...

2023-05-12 | MTBLS7584 | MetaboLights
MetabolomicsResearch on the microbiota and metabolic characteristics of type 2 chronic rhinosinusitis based on the analysis of 16S amplicon sequencing combined with metabolomics

Objective:

To investigate the diversity of nasal microbiota and metabolic characteristics of patients with Type 

2 chronic rhinosinusitis, as well as the interactions and potential regulatory relationships between 

the nasal microbiota and their metabolites by conducti...

2025-10-21 | MTBLS13192 | MetaboLights
TranscriptomicsRNA-seq of Staphylococcus aureus isolates from chronic rhinosinusitis patients (CSS) against healthy individuals
S. aureus isolates from chronic rhinosinusitis patients and healthy individuals were cultured overnight. The strains belonged to clonal complexes CC7 (CSS66 and MIN142) and CC15 (CSS126 and MIN93) that are both prevalent in Germany. These isolates have previously been characterized in Tuchscherr, L....
ORGANISM(S): Staphylococcus aureus 
2026-02-12 | E-MTAB-16578 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis of epithelial and fibroblast cells in chronic rhinosinusitis
Chronic rhinosinusitis without polyps (CRSsNP) is typified by inflammation of the sinonasal epithelium and the development of fibrosis. The precise pathophysiology of this common condition remains elusive. Here we aim to investigate the transcriptome (RNA transcripts in the cell) of the component ...
ORGANISM(S): Homo sapiens 
2015-12-31 | E-GEOD-69093 | biostudies-arrayexpress
UnknownEarly life risk factors for chronic sinusitis: A longitudinal birth cohort study.
Not available
S-EPMC5937937 | biostudies-literature
UnknownReliability, validity and responsiveness of a Norwegian version of the Chronic Sinusitis Survey.
Not available
S-EPMC1468424 | biostudies-literature
UnknownPathways analysis of molecular markers in chronic sinusitis with polyps.
Not available
S-EPMC4164309 | biostudies-literature
ProteomicsS100A4/TCF complex transcription regulation drives epithelial-mesenchymal transition in chronic sinusitis through Wnt/GSK-3β/β-catenin signaling
Chronic rhinosinusitis (CRS) is closely associated with remodelling of nasal mucosal tissue during a prolonged inflammatory process, and epithelial mesenchymal transition (EMT) is thought to be involved in this process, but the underlying mechanisms driving this progression are unclear. Using a high...
ORGANISM(S): Homo sapiens (Human) 
2022-02-21 | PXD030884 | Pride
Emt S100a4 Epigenetic regulation Crs Inflammation 
UnknownOutcomes of chronic frontal sinusitis treated with ethmoidectomy: a prospective study.
Not available
S-EPMC4921290 | biostudies-literature
UnknownIntra-oral low level laser therapy in chronic maxillary sinusitis: A new and effective recommended technique.
Not available
S-EPMC4663055 | biostudies-literature
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