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TranscriptomicsSOX11-positive and SOX11-knockdown xenograft derived tumor Gene Expression Profilings
The neural transcription factor SOX11 is overexpressed in aggressive lymphoid neoplasms mainly in mantle cell lymphoma (MCL). We have recently demonstrated SOX11 tumorigenic potential in vivo by showing a significant reduction on tumor growth of SOX11-knockdown MCL cells in xenograft experiments, co...
ORGANISM(S): Homo sapiens 
2014-11-04 | E-GEOD-52892 | biostudies-arrayexpress
ProteomicsddDT results from 2014 MCP alpha-lytic protease proteomics paper
ddDT runs of peptides from four separate protease digestions. CID for z=2, ETD for z>=3
ORGANISM(S): Schizosaccharomyces Pombe (ncbitaxon:4896) 
2015-01-30 | MSV000079025 | MassIVE
ProteomicsProteomics approach unravels early changes in Human Fibro-blasts-Pancreatic Ductal Adenocarcinoma cells crosstalk
Pancreatic ductal adenocarcinoma (PDAC) is a leading causes of cancer mortality worldwide. Non-specific symptoms, lack of biomarkers in the early stages, and drug resistance due to the presence of a dense fibrous stroma all contribute to poor outcome of this disease. The extracellular matrix of PDAC...
ORGANISM(S): Homo sapiens (Human) 
2022-05-20 | PXD030974 | Pride
Cancer associated fibroblasts  pdac microenvironment  proteomics  ingenuity pathway analysis 
ProteomicsCTCF loss has limited effects on genome architecture in Drosophila despite critical regulatory functions.
Proteins co-purifying with recombinantly purified and N-terminally GFP-3C-tagged CTCF N-terminus (amino acids 1-293) produced in bacteria were identified by incubating the tagged bait with soluble nuclear protein extracts from 0-12h hour-old wildtype (OregonR strain) Drosophila melanogaster embryos.
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2021-01-18 | PXD019487 | Pride
Genome organization Silencers 
ProteomicsProteomics investigation of Nucleostemin role in Nucleo-phosmin mutated OCI-AML 3 cell line
Nucleostemin (NS; product of the GNL3 gene) is a nucleolar/nucleoplasm shuttling GTPase whose levels are high in stem cells while rapidly decreasing upon differentiation. NS levels are also high in several solid and hematological neoplasms, including acute myeloid leukemia (AML). While a role in tel...
ORGANISM(S): Homo sapiens (Human) 
2022-08-11 | PXD034012 | Pride
Nucleophosmin Nucleostemin Shotgun proteomics Acute myeloid leukemia 
ProteomicsEssential role of Cp190 in physical and regulatory boundary formation in Drosophila
Animal genomes fold into contact domains defined by enhanced internal contact frequencies with debated functions in establishing independent gene regulatory domains. A large fraction of contact domains in mammals are formed by stalling of chromosomal loop-extruding cohesin by CTCF at domain boundari...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2022-05-30 | PXD027795 | Pride
Genome architecture Development Drosophila 
UnknownThe European Vasculitis Society 2016 Meeting Report.
Not available
S-EPMC5733672 | biostudies-literature
ProteomicsComparative analysis of high molecular mass subproteomes of Bothrops snake venoms
Snake venoms are extremely active biological secretions containing primarily various classes of enzymes. The genus Bothrops comprises various pit viper species that represent the most medically significant taxa in Central and South America, accounting for more human envenomations and fatalities than...
ORGANISM(S): Bothrops neuwiedi Bothrops moojeni Bothrops insularis Bothrops cotiara Bothrops jararacussu Bothrops leucurus Acyrthosiphon pisum (Pea aphid) Bothrops jararaca (Jararaca) (Bothrops jajaraca) Bothrops brazili 
2019-03-05 | PXD012088 | Pride
Snake venom Mass spectrometry Enzymes Proteome 
ProteomicsEarly response of C2C12 myotubes to a sub-cytotoxic dose of hemorrhagic metalloproteinase HF3 from Bothrops jararaca venom
Manifestations of local tissue damage, such as hemorrhage and myonecrosis, are among the most dramatic effects of envenomation by viperid snakes. Snake venom metalloproteinases (SVMPs) of the P-III class are main players of the hemorrhagic effect due to their activities in promoting blood vessel dis...
ORGANISM(S): Mus musculus (Mouse) 
2019-02-25 | PXD011274 | Pride
C2c12 myotubes  hf3  snake venom metalloproteinase  peptidomics  proteomics 
UnknownA TNFSF13B functional variant is not involved in systemic sclerosis and giant cell arteritis susceptibility.
Not available
S-EPMC6306228 | biostudies-literature
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