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ProteomicsBAG3 regulates cilia homeostasis of glioblastoma via its WW domain
The multidomain protein BAG3 exerts pleiotropic oncogenic functions in many tumor entities including glioblastoma (GBM). Here we compared BAG3 protein-protein interactions in either adherently cultured or stem-like cultured U251 GBM cells. In line with BAG3´s putative role in stemness, identified in...
ORGANISM(S): Homo sapiens (Human) 
2024-04-09 | PXD050279 | Pride
Cilia homeostasis Stemness Yap1 Ww domain Glioblastoma Bag3 Yap1 signaling Primary cilia 
ProteomicsA conserved mechanism for the retrieval of polyubiquitinated proteins from cilia
The temporospatial distribution of proteins within cilia is regulated by intraflagellar transport (IFT), wherein molecular trains shuttle between the cell body and cilium. Defects in this process impair various signal-transduction pathways and cause ciliopathies. Although K63-linked ubiquitination a...
ORGANISM(S): Chlamydomonas reinhardtii Leishmania tarentolae Sus scrofa domesticus (domestic pig) 
2026-06-29 | PXD062789 | Pride
Intraflagellar transport Flagella Hedgehog signaling Ubiquitin Cilia 
MetabolomicsMesenchymal stromal cells secretome restores bioenergetic and redox homeostasis in human proximal tubule cells after ischemic injury

BACKGROUND: Ischemia/reperfusion injury (IRI) is the leading cause of acute kidney injury (AKI). The current standard of care focuses on supporting kidney function, stating the need for more efficient and targeted therapies to enhance repair. Mesenchymal Stromal Cells (MSCs) and ...

2023-10-16 | MTBLS6279 | MetaboLights
UnknownNeuronal cilia in energy homeostasis.
Not available
S-EPMC9773564 | biostudies-literature
UnknownCilia density and flow velocity affect alignment of motile cilia from brain cells.
Not available
S-EPMC7790191 | biostudies-literature
ProteomicsIn vivo proximity labeling proteomics with cilia targeted V5-TurboID-eGFP transgenic mouse identified Rpap3 and Ak8 as regulators of motile cilia function
Cilia are indispensable for the development and homeostasis of almost all organ systems, and compromised cilia structure and function lead to highly clinical and genetic heterogeneous diseases collected named as ciliopathy. Cilia biology and ciliopathy patho-mechanism remains largely underexplored. ...
ORGANISM(S): Mus Musculus 
2025-06-14 | PXD065070 |
GenomicsBBS7 -SHH signaling activity regulates primary cilia for periodontal homeostasis
BBS7 -SHH signaling activity regulates primary cilia for periodontal homeostasis
PRJNA782351 | ENA
TranscriptomicsCFAP298 governs dynein arm protein homeostasis to ensure motile cilia function
This project investigates the role of CFAP298 in the regulation of motile cilia function, with a particular focus on dynein arm protein homeostasis. We examine how CFAP298 contributes to the proper maintenance, assembly, and stability of dynein arm components required for effective ciliary motility....
ORGANISM(S): Mus musculus 
2026-08-30 | GSE345015 | GEO
UnknownPrimary cilia and aberrant cell signaling in epithelial ovarian cancer.
Not available
S-EPMC3555760 | biostudies-literature
UnknownTau-tubulin kinase 2 restrains microtubule-depolymerizer KIF2A to support primary cilia growth.
Not available
S-EPMC11809056 | biostudies-literature
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