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ProteomicsQuantitative proteomics of cytokine-induced memory-like (CIML) NK cells
NK cells from healthy donors were isolated from peripheral blood and stimulated overnight with IL-12/15/18 to induce a memory-like phenotype. After 7 days of culture, the phenotype and degranulation potential of CIML NK cells was characterized in two distinct NK cell subsets: CD16+/CD56+ and CD16−/C...
ORGANISM(S): Homo sapiens (Human) 
2025-07-14 | PXD059190 | Pride
Lc-msms Cd16+cd56+ Itraq8plex isobaric labeling Quantitative proteomics Ciml nk cells Cd16−cd56+ 
TranscriptomicsTranscriptome analysis of TIML- and CIML-NK cells
NK cells may acquire under certain conditions features of adaptive immune cells. As the functional role of memory NK cells in cancer has so far remained elusive, we reasoned whether tumor-priming itself might promote memory NK cell generation. We provide substantial evidence that independent from pr...
ORGANISM(S): Homo sapiens 
2016-04-15 | E-MTAB-4606 | biostudies-arrayexpress
TranscriptomicsEfficient arming of memory-like NK cells with a TCR-like CAR for treating acute myeloid leukemia with NPM1 mutation
We showed Cytokine induced memory-like (CIML) human NK cells have higher trasduction efficiency with CAR lentivirus for therapeutics. We performed single cell RNAseq analysis to comprehensively understand the transcripttion difference between NPM1c-CAR-mb15 CIML NK cells and CAR-negative CIML NK cel...
ORGANISM(S): Homo sapiens 
2021-10-26 | GSE186115 | GEO
UnknownCD56<sup>bright</sup> cytokine-induced memory-like NK cells and NK-cell engagers synergize against non-small cell lung cancer cancer-stem cells.
Not available
S-EPMC11822435 | biostudies-literature
UnknowniRGD-modified memory-like NK cells exhibit potent responses to hepatocellular carcinoma.
Not available
S-EPMC10022190 | biostudies-literature
TranscriptomicsCytokine-induced Expandable Memory NK Cells with Significant Metabolic, Epigenetic Remodeling, and Persistence Properties
Recent investigations have indicated that NK cells induced overnight with IL-12/15/18 cytokines possess memory-like characteristics (refers as CIML NK, cytokine induced memory-like NK cells), demonstrating enhanced effector function and prolonged persistence. Preclinical studies and very early clini...
ORGANISM(S): Homo sapiens 
2026-06-30 | GSE311121 | GEO
GenomicsCytokine-induced Expandable Memory NK Cells with Significant Metabolic, Epigenetic Remodeling, and Persistence Properties
Cytokine-induced Expandable Memory NK Cells with Significant Metabolic, Epigenetic Remodeling, and Persistence Properties
PRJNA1368698 | ENA
UnknownCytokine-Induced Memory-Like NK Cells: From the Basics to Clinical Applications.
Not available
S-EPMC9114299 | biostudies-literature
UnknownNovel tetrameric bispecific KK-LC-1×CD16A-armed memory-like NK cells enhance antitumor efficacy in gastric cancer.
Not available
S-EPMC12516970 | biostudies-literature
GenomicsEfficient arming of memory-like NK cells with a TCR-like CAR for treating acute myeloid leukemia with NPM1 mutation
Efficient arming of memory-like NK cells with a TCR-like CAR for treating acute myeloid leukemia with NPM1 mutation
PRJNA772690 | ENA
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