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ProteomicsCritical functions of FAM134 family members in endoplasmic reticulum remodeling, ER-phagy and collagen quality control
Degradation of the endoplasmic reticulum (ER) by selective autophagy (ER-phagy) is vital for cellular homeostasis. Here, we introduce FAM134A/RETREG2 and FAM134C/RETREG3 as new ER-phagy receptors. FAM134A and FAM134C exist in a relatively inactive state under basal conditions and require an activati...
ORGANISM(S): Homo sapiens (Human) 
2021-06-23 | PXD025626 | Pride
Collagen Fam134 Endoplasmic reticulum Er-phagy Retreg Autophagy U2os. 
ProteomicsAn mTORC1-CK2 axis controls starvation induced ER-phagy via FAM134C
The degradation of endoplasmic reticulum (ER) via selective autophagy is driven by the ER-phagy receptors that facilitate the incorporation of ER-fragments into nascent autophagosomes. How these receptors are regulated, in response to ER-phagy-inducing stimuluses, is largely unknown. Here we propose...
ORGANISM(S): Homo sapiens (Human) Rattus norvegicus (Rat) 
2022-10-14 | PXD030451 | Pride
Human Fam134c Autophagy Rat Ck2 Mtorc1 Er-phagy 
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