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ProteomicsMyelin proteome differences in old and young mice
Aging of the peripheral nervous system (PNS) is associated with structural and functional changes that lead to a reduction in regenerative capacity and the development of age-related peripheral neuropathy. Myelin is a central component in maintaining physiological peripheral nerve function, and dif...
ORGANISM(S): Mus musculus (Mouse) 
2023-10-19 | PXD040719 | Pride
Myelin Peripheral nervous system Neuropathy 
ProteomicsNutlin-3a-induced changes in the proteome of parental and RFX7 knock-out U2OS cells
Mass spectrometry-based whole proteome analysis of parental and RFX7 knock-out U2OS cells treated with 10 µM Nutlin-3a or DMSO solvent control. Ten biological replicates were used.
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD024869 | Pride
Proteomics Rfx7 Nutlin Tumor 
ProteomicsIntratumoral magnetic hyperthermia in combination with 5-fluorouracil induces thrombogenic collagen fibers, cellular stress, and immune responses in heterotopic human colon cancer in mice
In this study we looked for the main protein pathway regulators which were responsible for the therapeutic impact on colon cancers when combining magnetic hyperthermia with the chemo-therapeutic agent 5-fluorouracil (5FU). In this context, chitosan-coated magnetic nanoparticles (MNP) functionalized ...
ORGANISM(S): Homo sapiens (Human) 
2021-11-10 | PXD027656 | Pride
Proteomics Tumor Magnetic hyperthermia 5fu 
ProteomicsMolecular characterization of hematopoietic stem cells after in vitro amplification on biomimetic 3D PDMS cell culture scaffoldsMolecular characterization of hematopoietic stem cells after in vitro amplification on biomimetic 3D PDMS cell culture scaffolds
Hematopoietic stem cell transplantation (HSCT) is successfully applied since the late 1950s, however, its efficacy still needs to be improved. A promising strategy is to transplant high numbers of pluripotent hematopoietic stem cells (HSCs). Therefore, an advanced ex vivo culture system is needed th...
ORGANISM(S): Homo sapiens (Human) 
2021-11-10 | PXD025849 | Pride
Hematopoietic stem cell transplantation (hsct) Proteomics Foxo Cholesterol Human hematopoietic stem cell (hsc) Srebp Biomimetic In vitro amplification 3d cell cultivation system Mtor Cell metabolism 
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