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TranscriptomicsExpression data identifying hypermethylated genes associated with acquired cisplatin resistance
Treatment-related DNA hypermethylation may play a role in creating drug resistant phenotypes by inactivating genes that are required for cytotoxicity, but there have been no genome-wide studies to systematically investigate methylation of individual genes following exposure to chemotherapy. We used ...
ORGANISM(S): Homo sapiens 
2010-04-12 | E-GEOD-19397 | biostudies-arrayexpress
TranscriptomicsThe transcriptional response of ovarian cancer cells to treatment with cisplatin (CDDP)
The transcriptional response to CDDP of three ovarian cancer cell lines was studied. These lines show different genetic profiles and display different susceptibilities to CDDP. The time and doses that resulted in the apoptotic death of each cell line was identified and used to study the expression p...
ORGANISM(S): Homo sapiens 
2013-12-31 | E-GEOD-38545 | biostudies-arrayexpress
TranscriptomicsMEK Inhibition Overcomes Cisplatin Resistance Conferred by SOS/MAPK Pathway Activation in Squamous Cell Carcinoma (SCC)
Genomic analyses of SCC have yet to yield significant strategies against pathway activation to improve treatment. Platinum-based chemotherapy remains the mainstay of treatment for SCC of different histotypes either as a single agent or alongside other chemotherapeutic drugs or radiotherapy; however,...
ORGANISM(S): Homo sapiens 
2015-08-05 | E-GEOD-66549 | biostudies-arrayexpress
TranscriptomicsDichloroacetate (DCA) prevents cisplatin-induced nephrotoxicity without compromising its anti-cancer properties.
The aim of this study was to compare the transcriptional changes that occur in the kidneys of mice administered cisplatin or DCA, or both, by RNA-seq. generation of RNA-seq datasets from mice subjected to 4 different treatments. 3 biological replicates per treatment. Saline treatment is control.
ORGANISM(S): Mus musculus 
2016-03-09 | E-GEOD-69652 | biostudies-arrayexpress
TranscriptomicsCDDP treatment of U2OS cells with NCOR and SMRT knock-down
We detected an interaction between checkpoint kinase Chk2 and some members of the NCOR/SMRT co-repressor complex. In order to study the role of gene repression in the checkpoint response to DNA damage, we performed RNA profiling in NCOR or SMRT knockdown cells after treztment with cisplatin. U2OS ce...
ORGANISM(S): Homo sapiens 
2012-02-06 | E-GEOD-34226 | biostudies-arrayexpress
GenomicsGenome-wide maps of methylation state in cisplatin sensitive and resistant ovarian cancer cell line
We report the application of methyl-binding protein sequencing (MBD-seq) to global identify aberrant methylation between cisplatin sensitive and resistant ovarian cancer cell lines Detection of aberrant methylation states between cisplatin sensitive and resistant cell lines
ORGANISM(S): Homo sapiens 
2012-04-10 | E-GEOD-31418 | biostudies-arrayexpress
ProteomicsProteome dynamics during cisplatin exposure in sensitive and resistant human lung cancer cells
Lung cancer is the leading cause of cancer-related deaths and its treatment is based in chemotherapy using platinum containing compounds, mainly cisplatin (CDDP). Many patients show resistance to CDDP leading to treatment failure. To understand the mechanisms involved in CDDP resistance in lung canc...
ORGANISM(S): Homo sapiens (Human) 
2023-03-10 | PXD021779 | Pride
Proteomics Drug resistance Boncat Cisplatin Lung cancer 
TranscriptomicsTranscription profiling of human A549 NSCLC cells cisplatin induced changes
Affymetrix high-density oligonucleotide microarray analysis was performed to analyse cisplatin-induced gene expression changes in A549 NSCLC cells. Cells were treated with 50 µM of cisplatin for 1 hour and incubated for a further 10 hours in drug-free media before the gene expression changes were i...
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-6410 | biostudies-arrayexpress
TranscriptomicsNoncoding RNA expression profiling of cisplatin-resistant cells derived from the A549 lung cell line (miRNA)
To determine the signaling networks that are dysregulated in cisplatin-resistant non-small cell lung cancer, noncoding RNA expression data were obtained from, and compared between, the lung adenocarcinoma cell line, A549, and its cisplatin-resistant derivative, A549/CDDP. Noncoding RNA expression da...
ORGANISM(S): Homo sapiens 
2013-01-15 | E-GEOD-43249 | biostudies-arrayexpress
TranscriptomicsNoncoding RNA expression profiling of cisplatin-resistant cells derived from the A549 lung cell line (lncRNA and mRNA)
To determine the signaling networks that are dysregulated in cisplatin-resistant non-small cell lung cancer, noncoding RNA expression data were obtained from, and compared between, the lung adenocarcinoma cell line, A549, and its cisplatin-resistant derivative, A549/CDDP. Noncoding RNA expression da...
ORGANISM(S): Homo sapiens 
2013-01-15 | E-GEOD-43493 | biostudies-arrayexpress
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