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ProteomicsThe CKS1/CKS2 proteostasis axis is crucial to maintain hematopoietic stem cell function
Long-term hematopoietic stem cells are rare, highly quiescent stem cells of the hematopoietic system with life-long self-renewal potential and the ability to transplant and reconstitute the entire hematopoietic system of conditioned recipients. Most of our understanding of these rare cells has relie...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-11 | PXD035984 | Pride
Proteostasis Lsk cells. Mouse Cks1 Cks2 Hematopoietic stem cells Proteomics 
ProteomicsCKS1-dependent proteostatic regulation has dual roles in combating acute myeloid leukemia whilst protecting normal hematopoiesis
Acute myeloid leukemia (AML) is an aggressive hematological disorder comprised of a hierarchy of quiescent leukemic stem cells and fast proliferating blasts with limited self-renewal ability. Significant plasticity in the AML epigenome and metabolome results in a high rate of drug resistance and rel...
ORGANISM(S): Homo sapiens (Human) 
2022-07-20 | PXD022754 | Pride
Proteostasis Chemotherapy Cks1 Hematopoiesis Aml Protein degradation 
GenomicsBalancing the CKS1/CKS2 proteostasis axis is critical to maintain hematopoietic stem cell function
Balancing the CKS1/CKS2 proteostasis axis is critical to maintain hematopoietic stem cell function
PRJNA877261 | ENA
TranscriptomicsBalancing the CKS1/CKS2 proteostasis axis is critical to maintain hematopoietic stem cell function
Investigation of the roles of CKS1 and CKS2 in murine haematopoiesis.
ORGANISM(S): Mus musculus 
2024-08-26 | GSE212789 | GEO
UnknownPADI3 plays an antitumor role via the Hsp90/CKS1 pathway in colon cancer.
Not available
S-EPMC6833139 | biostudies-literature
UnknownCks1 is required for tumor cell proliferation but not sufficient to induce hematopoietic malignancies.
Not available
S-EPMC3356264 | biostudies-literature
UnknownOverexpression of Cks1 is associated with poor survival by inhibiting apoptosis in breast cancer.
Not available
S-EPMC12160252 | biostudies-literature
Unknownp27T187A knockin identifies Skp2/Cks1 pocket inhibitors for advanced prostate cancer.
Not available
S-EPMC5112153 | biostudies-literature
UnknownCks1 enhances transcription efficiency at the GAL1 locus by linking the Paf1 complex to the 19S proteasome.
Not available
S-EPMC3811570 | biostudies-literature
UnknownCryo-EM structure of SKP1-SKP2-CKS1 in complex with CDK2-cyclin A-p27KIP1.
Not available
S-EPMC10318019 | biostudies-literature
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