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Unknownβ-Catenin in Dendritic Cells Negatively Regulates CD8 T Cell Immune Responses through the Immune Checkpoint Molecule Tim-3.
Not available
S-EPMC11125945 | biostudies-literature
ProteomicsE3 ubiquitin ligase RNF213 employs a non-canonical zinc finger active site and is allosterically regulated by ATP
RNF213 is a giant E3 ubiquitin ligase and a major susceptibility factor of Moyamoya disease, a cerebrovascular disorder that can result in stroke or death. In the cell, RNF213 is involved in lipid droplet formation, lipotoxicity, hypoxia, and NF-κB signaling, but its exact function in these processe...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2026-08-18 | PXD025992 | Pride
Rnf213 ube2l3 abp 
ProteomicsMoyamoya disease factor RNF213 is a giant E3 ligase with a dynein-like core and a distinct ubiquitin-transfer mechanism
RNF213 is the major susceptibility factor for Moyamoya disease, a progressive cerebrovascular disorder that often leads to brain stroke in adults and children. Characterization of disease-associated mutations has been complicated by the enormous size of RNF213. Here we present the cryo-EM structure ...
ORGANISM(S): Mus musculus (Mouse) 
2020-06-24 | PXD018701 | Pride
Rnf213 Mouse E3-ligase 
ProteomicsUNC-45 assisted myosin folding depends on a conserved FX3HY motif implicated in Freeman Sheldon Syndrome
Myosin motors are critical for diverse motility functions ranging from cytokinesis and endocytosis to muscle contraction. The UNC-45 chaperone controls myosin function mediating the folding, assembly, and degradation of the muscle protein. Here, we analyze the molecular mechanism of UNC-45 as a hub ...
ORGANISM(S): Caenorhabditis elegans 
2024-07-25 | PXD040428 | Pride
Ufd-2 Myopathy Mhc-b Myo4 Protein quality control Crosslinking mass spectrometry Ubiquitin proteasome system Unc-45 Molecular chaperones Myosin proteostasis 
UnknownMouse RNF213 double ATPase mutant (Walker B3, Walker B4) in presence of ATP
Not available
EMPIAR-12529 | biostudies-other
UnknownMouse RNF213 coupled to a UBE2L3 activity-based probe in presence of ATPγS
Not available
EMPIAR-12528 | biostudies-other
UnknownCryo-EM micrographs of full-length human BIRC6 dimer
Not available
EMPIAR-11430 | biostudies-other
UnknownCryo-EM micrographs of full-length human BIRC6 dimer with a bound DIABLO (SMAC) homodimer
Not available
EMPIAR-11431 | biostudies-other
UnknownCryo-EM micrographs of purified human BIRC6 in presence of HTRA2
Not available
EMPIAR-12563 | biostudies-other
UnknownCryo-EM micrographs of purified human BIRC6 in presence of CASP9
Not available
EMPIAR-12562 | biostudies-other
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