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ProteomicsMitochondrial dysfunction underlies cell cycle arrest and tubular hypoplasia in ClC-Kb-deficient Bartter syndrome mice
The pathogenesis of Bartter syndrome (BS) has long been attributed to decreased NaCl reabsorption in the thick ascending limb of Henle’s loop (TAL). By studying Clc-k2 (mouse ortholog of ClC-Kb)-knockout (Clc-k2-/-) mice, we recently uncovered an additional mechanism in which loss of transport funct...
ORGANISM(S): Mus musculus (Mouse) 
2026-07-09 | PXD069389 | Pride
Metabolism Clc-k2 Mitochondria Cell cycle Bartter syndrome type 3 
UnknownImpairment in renal medulla development underlies salt wasting in Clc-k2 channel deficiency.
Not available
S-EPMC8564913 | biostudies-literature
UnknownIGF-1 and insulin exert opposite actions on ClC-K2 activity in the cortical collecting ducts.
Not available
S-EPMC4281695 | biostudies-literature
UnknownDual regulation of the native ClC-K2 chloride channel in the distal nephron by voltage and pH.
Not available
S-EPMC5004338 | biostudies-literature
UnknownClC-K2 Cl- channel allows identification of A- and B-type of intercalated cells in split-opened collecting ducts.
Not available
S-EPMC9014849 | biostudies-literature
UnknownAngiotensin II increases activity of the ClC-K2 Cl- channel in collecting duct intercalated cells by stimulating production of reactive oxygen species.
Not available
S-EPMC7949157 | biostudies-literature
TranscriptomicsClC-Kb deficiency inhibits the proliferation and mitochondrial metabolism of renal tubules
Our previous study demonstrates that ClC-Kb chloride channel deficiency in Bartter syndrome (BS) type 3 not only impairs transport activity but also affects the development of the thick ascending limbs (TALs) and possibly distal convoluted tubules (DCTs). This developmental defect is important to th...
ORGANISM(S): Mus musculus 
2026-07-09 | GSE307980 | GEO
UnknownTranscriptional regulation of the CLC-K1 promoter by myc-associated zinc finger protein and kidney-enriched Kruppel-like factor, a novel zinc finger repressor.
Not available
S-EPMC86286 | biostudies-literature
UnknownNitric oxide mediates ET-1-induced-inhibition of NPPB-sensitive Cl<sup>-</sup> currents in the early distal convoluted tubule of the mouse kidney.
Not available
S-EPMC12925561 | biostudies-literature
GenomicsClC-Kb deficiency inhibits the proliferation and mitochondrial metabolism of renal tubules
ClC-Kb deficiency inhibits the proliferation and mitochondrial metabolism of renal tubules
PRJNA1327916 | ENA
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