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MetabolomicsMulti-omics and biophysical phosphoproteomics uncover functional phosphorylation networks of BRAFV600E-driven signaling

Dysregulated kinase activity drives oncogenic signalling, perturbs cellular homeostasis, and promotes tumour progression. Despite major success in targeting kinases therapeutically, the downstream consequences of kinase inhibition and the mechanisms underlying drug resistance remain incompletely ...

2025-12-09 | MTBLS7390 | MetaboLights
UnknownIntegrating phosphoproteomics into the clinical management of prostate cancer.
Not available
S-EPMC5309189 | biostudies-literature
ProteomicsFAS Inhibited Proteomics and Phosphoproteomics Profiling of Colorectal Cancer Spheroids shows Activation of Ferroptotic Death Mechanism
Colorectal cancer (CRC) is projected to become the third most diagnosed and third most fatal cancer in the United States by 2024, with early onset CRC on the rise. Research is constantly underway to discover novel therapeutics for the treatment of various cancers to improve patient outcomes and surv...
ORGANISM(S): Homo sapiens (Human) 
2024-08-10 | PXD050987 | Pride
Phosphoproteomics Mass spectrometry Colorectal cancer Cancer Proteomics Data-independent acquisition Spheroids 
ProteomicsPhosphoproteomics defines two biologically distinct groups of KMT2A rearranged acute myeloid leukaemia with different drug response phenotypes
Acute myeloid leukemia (AML) is a disease with poor outcome but patients harbouring certain chromosomal rearrangements or complex karyotypes have particularly adverse prognosis. For these patients, targeted therapies have not yet made a significant clinical impact. To understand the molecular landsc...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD032980 | Pride
Aml Phosphoproteomics Genomics Kmt2a Impdh Drug screen Nucleolus Proteomics 
ProteomicsPhosphoproteomics identifies determinants of PAK inhibitor sensitivity in AML cells
Background The p21 activated kinases (PAK) are frequently dysregulated in cancer and have central roles in oncogenic signalling, prompting the development of PAK inhibitors (PAKi) as anticancer agents. However, such compounds have not reached clinical use because, at least partially, there is a lim...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD056514 | Pride
Acute myeloid leukaemia Phosphoproteomics Machine learning Kinase inhibitors Pak inhibitors Target therapy Pf-3758309 Proteomics Biomarkers Cancer 
ProteomicsComparative phosphoproteomics reveals the role of AmpC β-lactamase phosphorylation in the clinical imipenem-resistant strain Acinetobacter baumannii SK17 (MaxQuant 1.3 and 1.4)
Nosocomial outbreaks of infections caused by multidrug-resistant Acinetobacter baumannii have emerged as a serious threat to human health. The phosphoproteomics of pathogenic bacteria have been investigated for their role in virulence regulation networks. In this study, we analyzed the phosphoproteo...
ORGANISM(S): Acinetobacter baumannii 
2015-10-27 | PXD002033 | Pride
Ampc phosphorylation Acinetobacter baumannii 
UnknownUsing phosphoproteomics data to understand cellular signaling: a comprehensive guide to bioinformatics resources.
Not available
S-EPMC7353784 | biostudies-literature
ProteomicsPhosphoproteomics Data of pancreatic cancers cells treated with anlotinib
Aberrant regulation of angiogenesis involves in the growth and metastasis of tumors, but angiogenesis inhibitors fail to improve overall survival of pancreatic cancer patients in previous phase III clinical trials. A comprehensive knowledge of the mechanism of angiogenesis inhibitors against pancrea...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD023345 | Pride
Phosphoproteomics data Anlotinib Pancreatic cancer 
Proteomics4D Label-Free Quantitative Phosphoproteomics of 12 Cell Samples (3 Groups with 4 Replicates Each)
4D Label-Free Quantitative Phosphoproteomics of 12 Cell Samples (3 Groups with 4 Replicates Each)
ORGANISM(S): Homo sapiens (Human) 
2026-06-11 | PXD074380 | Pride
Xa04306lpst 
ProteomicsEvaluation of phospho-tyrosine antibodies for label-free phosphoproteomics
In the past decade multiple tyrosine kinase inhibitors (TKIs) have been implemented in standard treatment regimens for patients with cancer. Unfortunately the majority of patients develops resistance to these drugs. Reliable tools for analysis of pharmacodynamic effects and drug resistance mechanism...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-10-21 | MSV000080270 | MassIVE
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