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TranscriptomicsGene expression profiles (stroma and epithelium) of prostate cancer mouse models (JOCK1, Pro-Cat M-CM-^W JOCK1, Ubi-Cat M-CM-^W JOCK1)
The fibroblast growth factor receptor (FGFR) and canonical Wnt signaling pathways are important regulators of carcinogenesis; however, the interaction between these two pathways in the context of prostate cancer (PCa) has not been fully elucidated. Using novel transgenic mouse models, we describe Wn...
ORGANISM(S): Mus musculus 
2014-01-07 | E-GEOD-41344 | biostudies-arrayexpress
ProteomicsA quantitative proteomics approach to monitor targeted protein degradation in M. smegmatis
Targeted protein degradation via the ubiquitin proteasome has been established in eukaryotes, however no application has been shown in bacteria so far. In the present work, selective protein degradation is shown using hetero bifunctional drugs, bringing substrates in close proximity to the bacterial...
ORGANISM(S): Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155) Bacteria 
2022-08-12 | PXD021505 | Pride
Mycobacteria Targeted protein degradation Protease Tpd 
UnknownThe diabetes control and complications trial/epidemiology of diabetes interventions and complications study at 30 years: overview.
Not available
S-EPMC3867999 | biostudies-literature
TranscriptomicsA family of secreted pathogenesis-related proteins in Candida albicans
Analyzing culture supernatants of yeast and hyphal cells of Candida albicans by mass spectrometry, we found two close homologues of pathogenesis-related (PR-) 1 proteins, Rbe1p and Rbt4p, in the secretome of this human pathogen. By sequence homology, we assigned three yet not characterized open read...
ORGANISM(S): Candida albicans 
2013-03-25 | E-GEOD-28212 | biostudies-arrayexpress
TranscriptomicsBlood feeding response of insecticide resistant mosquitoes from Ghana, GAH strain
Anopheles gambiae S form adults were drawn from the GAH laboratory colony that originated from the Ahafo region in Ghana. The GAH colony exhibits extensive insecticide resistance (bendiocarb, DDT, dieldrin, permethrin, deltamethrin). Gene expression was compared between blood-fed and sugar-fed femal...
ORGANISM(S): Anopheles gambiae 
2013-08-30 | E-MTAB-1621 | biostudies-arrayexpress
Transcriptomics"Calling Cards" for DNA-binding proteins in mammalian cells
The ability to chronicle transcription factor binding events throughout the development of an organism would facilitate mapping of transcriptional networks that control cell fate decisions. We describe a method for permanently recording protein-DNA interactions in mammalian cells. We endow transcri...
ORGANISM(S): Homo sapiens 
2011-12-31 | E-GEOD-34791 | biostudies-arrayexpress
TranscriptomicsKc167 Replication Origins
modENCODE_submission_709 This submission comes from a modENCODE project of David MacAlpine. For full list of modENCODE projects, see http://www.genome.gov/26524648 Project Goal: Early origins of replication were identified by treating cells with hydroxyurea (HU), a potent inhibitor of nucleotide syn...
ORGANISM(S): Drosophila melanogaster 
2010-05-15 | E-GEOD-17285 | biostudies-arrayexpress
MetabolomicsFirefly genomes illuminate parallel origins of bioluminescence in beetles
Fireflies and their luminous courtships have inspired centuries of scientific study. Today firefly luciferase is widely used in biotechnology, but the evolutionary origin of bioluminescence within beetles remains unclear. To shed light on this long-standing question, we sequenced the genomes of two ...
2018-09-14 | MTBLS698 | MetaboLights
TranscriptomicsRegulation of NUMB alternative splicing by RBM5, RBM6 and RBM10 controls cancer cell proliferation
RBM5, a regulator of alternative splicing of apoptotic genes, and its close homologues, RBM6 and RBM10, are RNA binding proteins frequently deleted or mutated in lung cancer. We report that RBM5/6 and RBM10 antagonistically regulate the proliferative capacity of cancer cells and display distinct pos...
ORGANISM(S): Homo sapiens 
2013-12-20 | E-GEOD-47431 | biostudies-arrayexpress
TranscriptomicsA next generation sequencing approach to profiling the host miRNA response to a bovine mastitis pathogen
Substantial evidence is now beginning to emerge that miRNAs, short, non-coding RNAs, which post-transcriptionally regulate gene expression, play a key role in the regulation of innate and adaptive immunity in humans and mice. Little is currently known, however, regarding the importance miRNAs in reg...
ORGANISM(S): Bos taurus 
2013-10-02 | E-GEOD-41278 | biostudies-arrayexpress
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