Sort   by:  
 Page size 
ProteomicsMablango_ClpP_HYTANE_P124_Lumos
This dataset consists of 6 raw MS files, acquired on Thermo Fusion Lumos mass spectrometer operated in Data Dependent Acquisition mode. Samples were generated by Keith Wong. Sample processing and mass spectrometry acquisition was performed by Cassandra Wong. Data analysis was performed by Cassandra...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-06-13 | MSV000089642 | MassIVE
UnknownTargeting the Mitochondrial Protease ClpP for Anticancer Therapy.
Not available
S-EPMC12700136 | biostudies-literature
UnknownMitochondrial Matrix Protease ClpP Agonists Inhibit Cancer Stem Cell Function in Breast Cancer Cells by Disrupting Mitochondrial Homeostasis.
Not available
S-EPMC9645232 | biostudies-literature
UnknownCaseinolytic protease P (CLPP) activated by ONC201 inhibits proliferation and promotes apoptosis in human epithelial ovarian cancer cells by inducing mitochondrial dysfunction.
Not available
S-EPMC8506775 | biostudies-literature
ProteomicsONC201 in combination with paxalisib for the treatment of H3K27-altered diffuse midline glioma
Diffuse midline gliomas (DMG), including diffuse intrinsic pontine gliomas (DIPGs), are the most lethal of all childhood cancers. Palliative radiotherapy is the only proven life-prolonging treatment, with patient survival 9-11 months. ONC201 shows preclinical and emerging clinical efficacy in DIPG. ...
ORGANISM(S): Homo sapiens (Human) 
2023-05-25 | PXD036245 | Pride
Dmg Clpp agonist Targeted therapies Dipg Onc201 
TranscriptomicsTR-107, An Agonist of Caseinolytic Peptidase Proteolytic Subunit, Disrupts Mitochondrial Metabolism and Inhibits the Growth of Human Colorectal Cancer Cells
Oxidative phosphorylation (OXPHOS) is an essential metabolic process for cancer proliferation and therapy resistance. The ClpXP complex maintains mitochondrial proteostasis by degrading misfolded proteins. Madera Therapeutics has developed a class of highly potent and selective small-molecule activa...
ORGANISM(S): Homo sapiens 
2024-12-18 | GSE261537 | GEO
GenomicsTR-107, An Agonist of Caseinolytic Peptidase Proteolytic Subunit, Disrupts Mitochondrial Metabolism and Inhibits the Growth of Human Colorectal Cancer Cells
TR-107, An Agonist of Caseinolytic Peptidase Proteolytic Subunit, Disrupts Mitochondrial Metabolism and Inhibits the Growth of Human Colorectal Cancer Cells
PRJNA1087398 | ENA
UnknownTR-107, an Agonist of Caseinolytic Peptidase Proteolytic Subunit, Disrupts Mitochondrial Metabolism and Inhibits the Growth of Human Colorectal Cancer Cells.
Not available
S-EPMC11614700 | biostudies-literature
UnknownCrystal structure of Mycobacterium tuberculosis ClpP1P2 suggests a model for peptidase activation by AAA+ partner binding and substrate delivery.
Not available
S-EPMC4217457 | biostudies-literature
UnknownStructure-guided development of selective caseinolytic protease P agonists as antistaphylococcal agents.
Not available
S-EPMC11722091 | biostudies-literature
Sort   by:  
 Page size