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TranscriptomicsEffects of ONC201 on mantle cell lymphoma cell lines
The small molecule ONC201 is toxic in vitro to multiple cell lines and primary tumor samples of mantle cell lymphoma (MCL) and acute myeloid leukemia, even ones with unfavorable genetic features (notably including TP53 inactivation) or acquired resistance to other agents. Because the mechanism of ac...
ORGANISM(S): Homo sapiens 
2016-02-20 | E-GEOD-68091 | biostudies-arrayexpress
ProteomicsProteomics and phosphoproteomics analysis of SUM159 cells upon ClpP activation with ONC201 and TR57 compounds
ClpP activators ONC201 and related small molecules (TR compounds, Madera Therapeutics), have demonstrated significant anti-cancer potential in an array of in vitro and in vivo studies, including clinical trials for refractory solid tumors. Though progress has been made in identifying specific phenot...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD038990 | Pride
Drug development Drug mechanism Cancer Clpp 
ProteomicsONC201 in combination with paxalisib for the treatment of H3K27-altered diffuse midline glioma
Diffuse midline gliomas (DMG), including diffuse intrinsic pontine gliomas (DIPGs), are the most lethal of all childhood cancers. Palliative radiotherapy is the only proven life-prolonging treatment, with patient survival 9-11 months. ONC201 shows preclinical and emerging clinical efficacy in DIPG. ...
ORGANISM(S): Homo sapiens (Human) 
2023-05-25 | PXD036245 | Pride
Dmg Clpp agonist Targeted therapies Dipg Onc201 
GenomicsEffect of TIC10/ONC201 on glioma cells
Effect of TIC10/ONC201 on glioma cells
PRJNA407791 | ENA
GenomicsPatient-derived HK-374 glioblastoma cells treated with radiation and ONC201
Patient-derived HK-374 glioblastoma cells treated with radiation and ONC201
PRJNA644645 | ENA
GenomicsGenome-wide gene expression profile of human DIPG cell lines (ONC201 treatment)
Genome-wide gene expression profile of human DIPG cell lines (ONC201 treatment)
PRJNA1001515 | ENA
GenomicsEffect of ONC201 and its derivatives (ONC206 and ONC212) on glioma cells
Effect of ONC201 and its derivatives (ONC206 and ONC212) on glioma cells
PRJNA412217 | ENA
TranscriptomicsAnti-cancer agent ONC201 activates early ATF4/DR5 upregulation, and cell death associated with XIAP inhibition
Two experiments were performed with ONC201/TIC10 in human colon cancer cell lines. The first experiment is TIC10-induced transcriptional changes at 48hrs in HCT116 p53-null cells (10uM). The second experiment is RKO cells, with and without acquired resistance to ONC201, treated with with ONC201 (10u...
ORGANISM(S): Homo sapiens 
2016-06-01 | E-GEOD-72865 | biostudies-arrayexpress
TranscriptomicsEffects of ONC201 on mantle cell lymphoma cell lines
The small molecule ONC201 is toxic in vitro to multiple cell lines and primary tumor samples of mantle cell lymphoma (MCL) and acute myeloid leukemia, even ones with unfavorable genetic features (notably including TP53 inactivation) or acquired resistance to other agents. Because the mechanism of ac...
ORGANISM(S): Homo sapiens 
2016-02-20 | GSE68091 | GEO
TranscriptomicsPatient-derived HK-374 glioblastoma cells treated with radiation and ONC201
RNASeq results for HK-374 treated with DMSO, radiation, ONC201 or radiation plus ONC201
ORGANISM(S): Homo sapiens 
2020-07-08 | GSE153982 | GEO
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