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GenomicsGene expression patterns in cMyBP-CΔC10mut HCM mice and cMyBP-C(t/t) DCM mice
Gene expression patterns in cMyBP-CΔC10mut HCM mice and cMyBP-C(t/t) DCM mice
PRJNA1090904 | ENA
TranscriptomicsGene expression patterns in cMyBP-CΔC10mut HCM mice and cMyBP-C(t/t) DCM mice
A 25-base pair deletion in the cardiac myosin binding protein-C (cMyBP-C) gene (MYBPC3), proposed to skip exon 33, modifies the C10 domain (cMyBP-CΔC10mut) and is associated with hypertrophic cardiomyopathy (HCM) and heart failure, affecting approximately 100 million South Asians. However, the molec...
ORGANISM(S): Mus musculus 
2024-03-22 | GSE262253 | GEO
ProteomicsHuman MyBP-C PKA-treated C0-C2 LC-MSMS
Cardiac myosin-binding protein C (cMyBP-C) is a thick filament–associated protein that influences actin–myosin interactions. cMyBP-C alters myofilament structure and contractile properties in a protein kinase A (PKA) phosphorylation–dependent manner. To determine the effects of cMyBP-C and its phosp...
ORGANISM(S): Homo sapiens (Human) 
2019-09-26 | PXD015391 | Pride
Human Lc-msms Myosin binding protein c Cmybp-c Phosphorylated Pka C0-c2 C0c2 
TranscriptomicsTranscriptomic profileing of iPSC-derived engineered cardiac tissue in which cMyBP-C have been ablated in the heterozygous and homozygous states on an isogenic background
Truncation mutations in cardiac myosin binding protein C (cMyBP-C), are common causes of hypertrophic cardiomyopathy (HCM). Heterozygous carriers present with classical HCM, while homozygous carriers present with early onset HCM that rapidly progress to heart failure. We used CRISPR-Cas9 to introduc...
ORGANISM(S): Homo sapiens 
2023-02-23 | GSE224129 | GEO
GenomicsTranscriptomic profileing of iPSC-derived engineered cardiac tissue in which cMyBP-C have been ablated in the heterozygous and homozygous states on an isogenic background
Transcriptomic profileing of iPSC-derived engineered cardiac tissue in which cMyBP-C have been ablated in the heterozygous and homozygous states on an isogenic background
PRJNA929945 | ENA
UnknownA Novel "Cut and Paste" Method for In Situ Replacement of cMyBP-C Reveals a New Role for cMyBP-C in the Regulation of Contractile Oscillations.
Not available
S-EPMC7577522 | biostudies-literature
UnknowncMyBP-C ablation in human engineered cardiac tissue causes progressive Ca2+-handling abnormalities.
Not available
S-EPMC10038829 | biostudies-literature
UnknownRLC phosphorylation amplifies Ca2+ sensitivity of force in myocardium from cMyBP-C knockout mice.
Not available
S-EPMC9930131 | biostudies-literature
UnknownAutoinhibition of cMyBP-C by its middle domains.
Not available
S-EPMC11963209 | biostudies-literature
UnknownE258K HCM-causing mutation in cardiac MyBP-C reduces contractile force and accelerates twitch kinetics by disrupting the cMyBP-C and myosin S2 interaction.
Not available
S-EPMC3753599 | biostudies-literature
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