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Next genereration sequencing reveals that CNAs associated with cyclin E overexpression tranlate into changes in transcriptional output.
Affymetrix OncoScan SNP arrays for profiling copy-number alterations (CNAs) and loss-of-heterozygosity (LOH) in colon cancer
Evaluation of CNAs in multiple myeloma tumors from Vk*MYC mice
Intratumor heterogeneity fosters the evolution of the genome leading to metastatic progress and therapy resistance . Here, we investigate the relative contribution of tumor aneuploidy and genomic heterogeneity involving CNAs and mutational events as prognostic and predictive determinants for disease...
ORGANISM(S): Homo sapiens 
2021-12-01 | GSE171777 | GEO
Transient cyclin E overexpression in human mammary epithelial cells leads to a distinct CNA signature. We carried out high throughput sequencing to determine if these CNAs translated into changes in transcription.
ORGANISM(S): Homo sapiens 
2020-08-30 | GSE136078 | GEO
Purpose: In uveal melanoma (UM) research, several cell lines are used in preclinical studies. Because Mel285 and Mel290 do not harbour typical GNAQ or GNA11 hotspot mutations, we aimed at better classifying them and understanding if we could find genetic causes to explain their protein and mRNA expr...
ORGANISM(S): Homo sapiens (Human) 
2024-07-16 | PXD051055 | Pride
Human colorectal cancer (CRC) is one of the better-understood systems for studying the genetics of cancer initiation and progression. To develop a cross-species comparison strategy for identifying CRC causative gene or genomic alterations, we performed array comparative genomic hybridization (aCGH) ...
ORGANISM(S): Canis lupus familiaris 
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