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ProteomicsUveal melanoma cell lines are representative for their tumour, except cell lines Mel285 and Mel290: the odd two out
Purpose: In uveal melanoma (UM) research, several cell lines are used in preclinical studies. Because Mel285 and Mel290 do not harbour typical GNAQ or GNA11 hotspot mutations, we aimed at better classifying them and understanding if we could find genetic causes to explain their protein and mRNA expr...
ORGANISM(S): Homo sapiens (Human) 
2024-07-16 | PXD051055 | Pride
G protein subunit alpha Mel285 Uveal melanoma Mel290 Cnas 
GenomicsEffect of depletion of A3B on gene expression of 92.1 cells and overexpression of A3B on gene expression of MEL290 cells
Effect of depletion of A3B on gene expression of 92.1 cells and overexpression of A3B on gene expression of MEL290 cells
PRJNA905401 | ENA
TranscriptomicsEffect of depletion of A3B on gene expression of 92.1 cells and overexpression of A3B on gene expression of MEL290 cells
To investigate the function of A3B, we established 92.1 cell lines with A3B knocked down and MEL290 cell lines with A3B overexpression. We then performed gene expression profiling analysis using data obtained from RNA-seq of 4 different cell lines with two replicates.
ORGANISM(S): Homo sapiens 
2023-06-07 | GSE218751 | GEO
UnknownProtein and mRNA Expression in Uveal Melanoma Cell Lines Are Related to GNA and BAP1 Mutation Status.
Not available
S-EPMC11268447 | biostudies-literature
UnknownEMT-associated factors promote invasive properties of uveal melanoma cells.
Not available
S-EPMC4548792 | biostudies-literature
GenomicsBET bromodomain inhibition potentiates ocular melanoma therapy by inducing cell cycle arrest
BET bromodomain inhibition potentiates ocular melanoma therapy by inducing cell cycle arrest
PRJNA976712 | ENA
GenomicsIn uveal melanoma Gα-protein GNA11 mutations convey a shorter disease-specific survival and are more strongly associated with loss of BAP1 and chromosomal alterations than Gα-protein GNAQ mutations
In uveal melanoma Gα-protein GNA11 mutations convey a shorter disease-specific survival and are more strongly associated with loss of BAP1 and chromosomal alterations than Gα-protein GNAQ mutations
PRJNA811514 | ENA
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