Sort   by:  
 Page size 
ProteomicsQuantitative Proteomics of Cochlear Tissues: Bilateral Comparisons in Guinea Pigs and Rats
The cochlea, a sensitive biosensor, detects sound waves and converts them into electrical signals the brain recognizes as sound. Damage to cochlear hair cells can release proteins, triggering biological responses that may impair hearing. Mass spectrometry-based proteomics offers insights into protei...
ORGANISM(S): Cavia porcellus (Guinea pig) Rattus norvegicus (Rat) 
2025-07-21 | PXD059025 | Pride
Mass-spectrometry Cochlear tissue Rat Proteomics Guinea pigs 
ProteomicsIsolation and Comprehensive Analysis of Cochlear Tissue-derived Small Extracellular Vesicles
Label-free quantitative proteomics analysis of CDsEVs, with the same amount of protein of cochlear tissues used as the control
ORGANISM(S): Mus Musculus 
PXD056591 |
ProteomicsUnraveling the Molecular Landscape of Lead-Induced Cochlear Synaptopathy: A Quantitative Proteomic Analysis
This study investigates how lead exposure triggers cochlear synaptopathy and hearing loss in mice. Young-adult CBA/J mice were given lead acetate in drinking water for 28 days. We assessed hearing thresholds, outer hair cell activity, and synaptic changes in the cochlea. Lead exposure raises hearing...
ORGANISM(S): Mus musculus (Mouse) 
2024-10-17 | PXD050415 | Pride
Pb Mouse Hearing loss Cochlea Lc-ms/ms 
TranscriptomicsIdentification of microRNA targets in the mammalian inner ear using a comprehensive transcriptome and proteome integrated approach
We have employed a novel approach for the identification of functionally important microRNA (miRNA)-target interactions using integrated miRNA, transcriptome and proteome profiles with advanced in silico analysis. By looking at both the transcript and protein levels of expression, a thorough coverag...
ORGANISM(S): Mus musculus 
2011-04-20 | E-GEOD-23081 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse CBA/CaJ cochlea gene expression profile
This data set is intended as a public resource documenting the identity of roughly 10,000 genes that are abundantly expressed in the mouse cochlea. The data have many uses, including for making comparisons with proteomics studies, and for comparisons of expression profiles with other mouse strains a...
ORGANISM(S): Mus musculus 
2008-11-13 | E-GEOD-13421 | biostudies-arrayexpress
ProteomicsProteome Comparison of Different-Aged Cochlea
Our work describes the application of mass spectrometry-based label-free quantitative proteomics for the identification of differentially expressed proteins between different-aged cochlea. We report proteins exclusively present as well as up- and downregulated in the cochlear sensory epithelium at ...
ORGANISM(S): Mus musculus (Mouse) 
2018-08-29 | PXD001973 | Pride
Cochlea Proteomics Sensory epithelium Development Quantitative mass spectrometry 
ProteomicsThe cargos and roles of small extracellular vesicles from cochlear explants in cisplatin-induced ototoxicity
Small extracellular vesicles (sEVs) play an important role in intercellular communication as well as pathological development. Here, to explore the roles of sEVs in the progression of cisplatin-induced ototoxicity, we isolated sEVs from the conditioned culture medium of cisplatin-induced cochlear ex...
ORGANISM(S): Mus musculus (Mouse) 
2025-09-01 | PXD052123 | Pride
Cisplatin-induced ototoxicity Sev Cltc Hspa8 Biomarkers Cct2 
ProteomicsProteomic analysis of cochlear perilymph in a mouse model of Alzheimer's disease
This study referred to the changes in protein abundance of App(NL-GF/NL-GF) and App(wt/wt) mice perilymph. Liquid chromatography-tandem mass spectrometry with MS2-based quantification of tandem mass tag was utilized.
ORGANISM(S): Mus Musculus (mouse) 
2024-04-15 | PXD046317 | JPOST Repository
ProteomicsCochlear Proteomics: Insights into the Auditory Pathophysiology
Hearing loss (HL) is a global disability caused by irreversible damage to cochlear hair cells, essential for sound transduction. In mammals, the inability to regenerate these cells results in permanent auditory deficits. Early postnatal mice exhibit a limited regenerative potential from supporting c...
ORGANISM(S): Mus musculus (Mouse) 
2026-10-05 | PXD058223 | Pride
Noise-induced hearing loss Omics data reuse Sensory epithelium regeneration Cochlear proteomics Auditory pathophysiology Nano lc-ms/ms 
UnknownBottom-up and shotgun proteomics to identify a comprehensive cochlear proteome.
Not available
S-EPMC4144434 | biostudies-literature
Sort   by:  
 Page size