Synthetic genome recoding offers a powerful approach to imparting new capabilities to organisms. While monumental achievements have been made in prokaryotes, genome-wide synonymous codon compression in eukaryotes remains challenging due to limited understanding of "design rules" and the physiologica...
The role of transfer (t)RNA cytosine methyl-transferases as epitranscriptomic regulators of brain proteomes remains unexplored. We report that fear memory and antidepressant-like behaviors are highly sensitive to bi-directional changes in Nsun2 tRNA methyltransferase activity in prefrontal cortex (P...
Biotin identification (BioID) is a proximity-dependent labeling technique to study protein-protein co-localization in vivo. Although BioID has been applied in animal cells, plants and yeast, the method remained to be established in filamentous fungi. In this study, we established BioID for the filam...
