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ProteomicsThe cohesin acetylation cycle controls chromatin loop length through a PDS5A brake mechanism
Cohesin structures the genome through the formation of chromatin loops and by holding together the sister chromatids. The acetylation of cohesin’s SMC3 subunit is a dynamic process that involves the acetyltransferase ESCO1 and deacetylase HDAC8. Here we show that this cohesin acetylation cycle contr...
ORGANISM(S): Homo sapiens (Human) 
2022-03-14 | PXD032185 | Pride
Cohesin acetylation cycle Ctcf Esco1 Pds5a Cohesin Hdac8 3d genome Wapl Chromatin loops Pds5b 
GenomicsThe cohesin acetylation cycle controls chromatin loop length through a PDS5A brake mechanism (Hi-C)
The cohesin acetylation cycle controls chromatin loop length through a PDS5A brake mechanism (Hi-C)
PRJNA632826 | ENA
UnknownThe cohesin acetylation cycle controls chromatin loop length through a PDS5A brake mechanism.
Not available
S-EPMC9205776 | biostudies-literature
GenomicsThe cohesin acetylation cycle controls chromatin loop length through a PDS5A brake mechanism (synthetic viability screen)
The cohesin acetylation cycle controls chromatin loop length through a PDS5A brake mechanism (synthetic viability screen)
PRJNA730827 | ENA
GenomicsThe Smc3 deacetylase Hos1 closes the cohesin acetylation cycle
Cohesion between sister chromatids is mediated by the chromosomal cohesin complex. In budding yeast, cohesin is loaded onto chromosomes during the G1 phase of the cell cycle. During S-phase, the replication fork-associated acetyltransferase Eco1 acetylates the cohesin subunit Smc3 to promote establi...
ORGANISM(S): Saccharomyces cerevisiae 
2010-06-10 | GSE22257 | GEO
UnknownHDAC8 mutations in Cornelia de Lange syndrome affect the cohesin acetylation cycle.
Not available
S-EPMC3443318 | biostudies-literature
OtherThe cohesin acetylation cycle controls chromatin loop length through a PDS5A brake mechanism (Hi-C)
Cohesin structures the genome through the formation of chromatin loops and by holding together the sister chromatids from S-phase until mitosis. The acetylation of cohesin’s SMC3 subunit is a dynamic process that involves the acetyltransferase ESCO1 and deacetylase HDAC8. Here we show that this cohe...
ORGANISM(S): Homo sapiens 
2022-03-14 | GSE150564 | GEO
OtherThe cohesin acetylation cycle controls chromatin loop length through a PDS5A brake mechanism (synthetic viability screen)
Cohesin structures the genome through the formation of chromatin loops and by holding together the sister chromatids from S-phase until mitosis. The acetylation of cohesin’s SMC3 subunit is a dynamic process that involves the acetyltransferase ESCO1 and deacetylase HDAC8. Here we show that this cohe...
ORGANISM(S): Homo sapiens 
2022-03-14 | GSE174627 | GEO
GenomicsSaccharomyces cerevisiae
The Smc3 deacetylase Hos1 closes the cohesin acetylation cycle
PRJNA128727 | ENA
UnknownReversible acetylation of HDAC8 regulates cell cycle.
Not available
S-EPMC11387496 | biostudies-literature
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