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ProteomicsHDAC8 regulates escape from BRAF inhibitor therapy in Melanoma: Phosphotyrosine Profiling
Melanoma cells are highly plastic and have the ability to switch to a dedifferentiated, invasive phenotype in response to multiple stimuli. Here, we show that exposure of melanoma cell lines and patient specimens to multiple stresses including BRAF-MEK inhibitor therapy, hypoxia and UV-irradiation ...
ORGANISM(S): Homo sapiens (Human) 
2020-07-07 | PXD012812 | Pride
Melanoma Braf Hdac8 
ProteomicsHDAC8 regulates escape from BRAF inhibitor therapy in Melanoma: IMAC Phosphoproteomics
Melanoma cells are highly plastic and have the ability to switch to a dedifferentiated, invasive phenotype in response to multiple stimuli. Here, we show that exposure of melanoma cell lines and patient specimens to multiple stresses including BRAF-MEK inhibitor therapy, hypoxia and UV-irradiation ...
ORGANISM(S): Homo sapiens (Human) 
2020-07-07 | PXD012813 | Pride
Melanoma Braf Hdac8 
ProteomicsHDAC8-mediated inhibition of EP300 drives a transcriptional state that increases melanoma brain metastasis
Melanomas are heterogeneous and adopt multiple transcriptional states that can confer an invasive phenotype and resistance to therapy. Little is known about the epigenetic drivers of these cell states, limiting our ability to regulate melanoma heterogeneity and tumor progression. Here we identify st...
ORGANISM(S): Homo sapiens (Human) Brassica oleracea var. botrytis (Cauliflower) 
2023-09-26 | PXD044471 | Pride
Brain metastasis Melanoma Hdac8 Acetylation 
ProteomicsLesion-dependent Hdac8 interactome
In this project anti-Hdac8 immunoaffinity purifications (IPs) of nerves isolated from WT and Hdac8 knock out mice were compared. Nerves were either crushed prior IP (lesion, CR) or not (no lesion, CO). IPs were performed 1 dpL. In total four IPs were performed.
ORGANISM(S): Mus musculus (Mouse) 
2024-12-02 | PXD046582 | Pride
Lc-msms Mouse Nerve Ip Hdac8 
GenomicsGene expression in HDAC8 and HDAC9 silencing keratinocyte
Gene expression in HDAC8 and HDAC9 silencing keratinocyte
PRJNA645303 | ENA
GenomicsHDAC8 mediated alterations in melanoma cell line gene expression
HDAC8 mediated alterations in melanoma cell line gene expression
PRJNA1003119 | ENA
GenomicsExploring HDAC8 related transcriptomic change in DNA damage response in AML
Exploring HDAC8 related transcriptomic change in DNA damage response in AML
PRJNA1312472 | ENA
ProteomicsDiscovery of a Highly Potent and Selective HDAC3 and HDAC8 PROTAC Dual Degrader
HDAC3 and HDAC8 are members of class I deacetylases involved in several biological mechanisms and represent a highly sought-after therapeutic target for drug development. It is historically challenging to develop selective deacetylase inhibitors due to their conserved catalytic domains. HDAC3 also h...
ORGANISM(S): Homo sapiens (Human) 
2023-07-18 | PXD040941 | Pride
Epigenetics Hdac3 Protac Histone deacetylase Hdac8 Degrader 
GenomicsOverexpression of HDAC8 establishes a unique gene signature in BRAF-mutant melanoma cells
Overexpression of HDAC8 establishes a unique gene signature in BRAF-mutant melanoma cells
PRJNA524923 | ENA
UnknownDiscovery of a Highly Potent and Selective HDAC8 Degrader: Advancing the Functional Understanding and Therapeutic Potential of HDAC8.
Not available
S-EPMC12832081 | biostudies-literature
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