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ProteomicsThe cohesin acetylation cycle controls chromatin loop length through a PDS5A brake mechanism
Cohesin structures the genome through the formation of chromatin loops and by holding together the sister chromatids. The acetylation of cohesin’s SMC3 subunit is a dynamic process that involves the acetyltransferase ESCO1 and deacetylase HDAC8. Here we show that this cohesin acetylation cycle contr...
ORGANISM(S): Homo sapiens (Human) 
2022-03-14 | PXD032185 | Pride
Cohesin acetylation cycle Ctcf Esco1 Pds5a Cohesin Hdac8 3d genome Wapl Chromatin loops Pds5b 
GenomicsLoss of Cohesin regulator PDS5A reveals repressive role of Polycomb loops
Loss of Cohesin regulator PDS5A reveals repressive role of Polycomb loops
PRJNA800030 | ENA
UnknownPDS5A and PDS5B differentially affect gene expression without altering cohesin localization across the genome.
Not available
S-EPMC9392266 | biostudies-literature
UnknownLoss of cohesin regulator PDS5A reveals repressive role of Polycomb loops.
Not available
S-EPMC10710464 | biostudies-literature
GenomicsPDS5A and PDS5B differentially affect gene expression without altering cohesin localization across the genome [RNA-seq]
PDS5A and PDS5B differentially affect gene expression without altering cohesin localization across the genome [RNA-seq]
PRJNA819063 | ENA
GenomicsPDS5A and PDS5B differentially affect gene expression without altering cohesin localization across the genome [ChIP-seq]
PDS5A and PDS5B differentially affect gene expression without altering cohesin localization across the genome [ChIP-seq]
PRJNA819447 | ENA
UnknownThe cohesin-associated protein Pds5A governs the meiotic spindle assembly via deubiquitination of Kif5B in oocytes.
Not available
S-EPMC11988415 | biostudies-literature
TranscriptomicsPDS5A and PDS5B differentially affect gene expression without altering cohesin localization across the genome [RNA-seq]
Purpose: Cohesin is an important structural regulator of the genome. Whether cohesin HEAT repeat accessory proteins PDS5A and PDS5B differentially contribute to cohesin function remains unclear. The purpose of this study is to interrogate how PDS5A and PDS5B affect cohesin localization and gene expr...
ORGANISM(S): Mus musculus 
2022-08-21 | GSE199255 | GEO
UnknownPds5A and Pds5B Display Non-redundant Functions in Mitosis and Their Loss Triggers Chk1 Activation.
Not available
S-EPMC7372117 | biostudies-literature
GenomicsPDS5A and PDS5B differentially affect gene expression without altering cohesin localization across the genome [ChIP-seq]
Purpose: Cohesin is an important structural regulator of the genome. Whether cohesin HEAT repeat accessory proteins PDS5A and PDS5B differentially contribute to cohesin function remains unclear. The purpose of this study is to interrogate how PDS5A and PDS5B affect cohesin localization and gene expr...
ORGANISM(S): Mus musculus 
2022-08-21 | GSE199354 | GEO
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