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MetabolomicsTranscriptome and metabolome changes in Chinese cedar during cold acclimation reveal the roles of flavonoids in needle discoloration and cold resistance

Cryptomeria fortunei growth and development are usually affected by low temperatures. Despite the evergreen nature of this species, most needles turn yellowish-brown in cold winters. The underlying discoloration mechanisms that cause this phenomenon in response to cold acclimation remain...

2022-08-12 | MTBLS3184 | MetaboLights
MetabolomicsBrown-fat-mediated tumour suppression by cold-altered global metabolism

Glucose uptake is essential for cancer glycolysis and is involved in non-shivering thermogenesis of adipose tissues. Most cancers use glycolysis to harness energy for their infinite growth, invasion and metastasis. Activation of thermogenic metabolism in brown adipose tissue (BAT) by cold an...

2022-08-12 | MTBLS4856 | MetaboLights
MetabolomicsMetabolomics-Based Analysis of Adaptive Mechanism of Eleutheronema tetradactylum to Low-Temperature Stress

Temperature is a critical environmental factor influencing fish physiology. Eleutheronema tetradactylum is an economically important warm-water species, but its response to long-term cold stress remains unclear. In this study, we exposed juvenile fish to 18 °C for 7 and 14 days and investigated h...

2026-09-08 | MTBLS15459 | MetaboLights
MetabolomicsTrehalose accumulation strategy enhancing cold stress response in Telenomus remus, a dominant egg parasitoid of Spodoptera frugiperda

Telenomus remus, an egg parasitoid capable of penetrating multi-layered egg masses, has emerged as a promising candidate for the biological control of Spodoptera frugiperda. Nevertheless, our prior investigations have uncovered that its limited cold tolerance represents a critical bottleneck in m...

2025-06-09 | MTBLS12473 | MetaboLights
MetabolomicsMouse Brown Adipose Tissue Lipidomics under Cold and Dietary Fat Interventions
This study investigates lipidomic remodeling in mouse brown adipose tissue under a 2 × 3 experimental design involving environmental condition and dietary fatty acid composition. Mice were maintained at room temperature with ad libitum feeding or exposed to 4°C cold conditions with 70% calorie restr...
2026-06-01 | MTBLS14642 | MetaboLights
MetabolomicsTranscriptomic and metabolomic comparison of two Kandelia obovata cultivas in response to cold wave
Temperature is the primary environmental factor that restricts the growth and distribution of mangrove plants. With the escalating severity of global climate change, Kandelia obovata has gained widespread recognition as an ideal species for investigating the response mechanisms of mangroves to cold ...
2024-09-27 | MTBLS9845 | MetaboLights
MetabolomicsMild cold exposure mitigates ischemic heart injury through indole-3-acetamide–AHR-mediated SMAD2 proteolysis

Ambient temperature profoundly influences organismal metabolism, physiology, and disease. While cold exposure is a well-recognized risk factor for the onset of myocardial infarction (MI), its impact on the injured heart after MI remains unexplored. Here,&nb...

2026-03-03 | MTBLS13965 | MetaboLights
MetabolomicsNatural polymorphism of ZmICE1 contributes to amino acid metabolism that impacts cold tolerance in maize

Cold stress negatively affects maize (Zea mays L.) growth, development and yield. Metabolic adjustments contribute to the adaptation of maize under cold stress. We show here that the transcription factor INDUCER OF CBF EXPRESSION 1 (ZmICE1) plays a prominent role in reprogramming amino a...

2022-10-31 | MTBLS4404 | MetaboLights
MetabolomicsCold exposure aggravates vein occlusion through non-shivering thermogenesis-induced thrombocytopoiesis
Vein occlusion (VO), including deep venous thrombosis (DVT) and retinal vein occlusion (RVO), is a common cause of multiple diseases that severely compromise the quality of life of affected individuals. Epidemiological evidence indicates that VO prevalence increases in cold seasons, yet the underlyi...
2026-07-08 | MTBLS14667 | MetaboLights
MetabolomicsLow-temperature induced neuro-oxidative stress and metabolic reprogramming in the brain of juvenile fourfinger threadfin (Eleutheronema tetradactylum)
This study investigated the effects of low-temperature stress on the brain metabolome of juvenile fourfinger threadfin (Eleutheronema tetradactylum). Using UHPLC-Q-TOF-MS-based untargeted metabolomics, we analyzed brain tissues from fish exposed to 28°C (control) and 18°C for 7 and 14 days. The aim ...
2026-07-22 | MTBLS15103 | MetaboLights
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