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ProteomicsA Long-Range Recruitment Mechanism for mTORC2 Phosphorylation of Akt
Study of the phosphorylation of human Akt1 (Akt) by mTOR complex 2 (mTORC2) in vitro. Akt was prepared by semi-synthesis, resulting in a non-phosphorylated C-tail, allowing unbiased study of the sites phosphorylated by mTORC2. Because enzymologic data showed that the canonical hydrophobic motif resi...
ORGANISM(S): Homo sapiens (Human) 
2026-02-02 | PXD048719 | Pride
Akt Agc kinase Mtorc2 Mtor Phosphorylation Hydrophobic motif 
ProteomicsEnzymatic Analysis of WWP2 E3 Ubiquitin Ligase Using Protein Microarrays Identifies Autophagy-Related Substrates
WWP2 is a HECT E3 ligase that targets protein Lys residues for ubiquitination. As a member of the NEDD4 family of E3 ligases, WWP2 is comprised of an N-terminal C2 domain, four central WW domains, and a C-terminal catalytic HECT domain. The peptide segment between the middle WW domains, the 2,3-link...
ORGANISM(S): Escherichia coli 
2022-05-20 | PXD031703 | Pride
Ubiquitination Protein microarray Wwp2 Autophagy receptor Lc-msms 
TranscriptomicsIdentification of Sox9-Regulated Pathways During the Secondary Transition Stage of Pancreas Development
Sox9 target genes were identified during the secondary transition stage of pancreas development by comparing gene expression in Sox9-ablated versus wild-type pancreata using microarray analysis. Sox9 was conditionally ablated during the secondary transition in the developing pancreas via recombinati...
ORGANISM(S): Mus musculus 
2012-08-01 | E-GEOD-28670 | biostudies-arrayexpress
TranscriptomicsTwo Histone/Protein Acetyltransferases, CBP and p300, Are Indispensable for Foxp3+ T-regulatory Cell Development and Function
T-regulatory (Treg) cells are important to immune homeostasis, and Treg cell deficiency or dysfunction leads to autoimmune disease. An histone/protein acetyltransferase (HAT), p300, was recently found important for Treg function and stability, but further insights into the mechanisms by which p300 o...
ORGANISM(S): Mus musculus 
2014-08-12 | E-GEOD-60318 | biostudies-arrayexpress
UnknownCBP binding outside of promoters and enhancers in Drosophila melanogaster.
Not available
S-EPMC4657240 | biostudies-literature
ProteomicsTime-resolved analysis reveals rapid dynamics and broad scope of the CBP/p300 acetylome
The acetyltransferases CBP and p300 are multifunctional transcriptional co-activators; however, their acetylation targets, site-specific acetylation kinetics, and function in proteome regulation are incompletely understood. We combined quantitative proteomics with novel CBP/p300-specific catalytic i...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Mus Musculus (ncbitaxon:10090) 
MSV000095981 | MassIVE
UnknownCBP Regulates Recruitment and Release of Promoter-Proximal RNA Polymerase II.
Not available
S-EPMC5826544 | biostudies-literature
GenomicsPromoter proximal pausing and its regulation by c-Myc in embryonic stem cells: ChIP-Seq
Recruitment of the RNA Polymerase II (Pol II) transcription initiation apparatus to promoters by specific DNA binding transcription factors is well recognized as a key regulatory step in gene expression. We describe here evidence that promoter-proximal pausing is a general feature of transcription ...
ORGANISM(S): Mus musculus 
2010-04-02 | E-GEOD-20530 | biostudies-arrayexpress
UnknownDeep profiling of multiple ischemic lesions in a large, multi-center cohort: Frequency, spatial distribution, and associations to clinical characteristics.
Not available
S-EPMC9453031 | biostudies-literature
UnknownOutcome after acute ischemic stroke is linked to sex-specific lesion patterns.
Not available
S-EPMC8172535 | biostudies-literature
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