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MetabolomicsMitochondrial NAD+ Deficiency in Vascular Smooth Muscle Impairs Collagen III Turnover to Trigger Aortic Disease

Aortic disease poses a significant mortality risk in adults, yet many of its underlying factors remain undiscovered. In this study, we identify mitochondrial NAD⁺ deficiency as a causal factor. Metabolomics analysis of 73 surgical aortic specimens revealed impaired NAD⁺ salvage and mitochondrial ...

2024-12-04 | MTBLS8062 | MetaboLights
ProteomicsLysyl hydroxylase 3 mediated post-translational modifications are required for proper biosynthesis of collagen a1a1a2(IV)
We performed proteomic identification of type IV collagen gel bands from wild-type and lysyl hydroxylase 3 knockout cells by LC-MS after trypsin digestion.
ORGANISM(S): Mus Musculus (mouse) 
2022-11-21 | PXD035051 | JPOST Repository
TranscriptomicsCollagen Dynamics and Transcriptional Profiling in Bleomycin-induced Pulmonary Fibrosis
Collagen deposition is a key process during idiopathic pulmonary fibrosis (IPF); however, little is known about the dynamics of collagen formation during disease development. Tissue samples of early stages of human disease are not readily available and it is difficult to identify changes in collagen...
ORGANISM(S): Mus musculus 
2013-05-26 | E-GEOD-37635 | biostudies-arrayexpress
TranscriptomicsCathepsin K Contributes to Cavitation and Collagen Turnover in Pulmonary Tuberculosis
Cavitation in tuberculosis (TB) enables highly efficient person-to-person aerosol transmission. Currently, a number of hypotheses exist regarding the mechanisms underlying this process. To explore this process, we undertook an unbiased next-generation transcriptional analysis of samples from cavity ...
ORGANISM(S): Oryctolagus cuniculus 
2015-11-03 | E-GEOD-68206 | biostudies-arrayexpress
MetabolomicsMedicarpin suppresses gastric cancer growth through modulation of mevalonate pathway-associated cholesterol biosynthesis
Background: Gastric cancer (GC) is an aggressive malignancy characterized by metabolic reprogramming, including dysregulated cholesterol biosynthesis. Medicarpin (Med), a natural isoflavan isolated from Radix Hedysari, has shown pharmacological potential; however, its anti-GC activity and metabolic ...
2026-10-02 | MTBLS15900 | MetaboLights
TranscriptomicsCollagen-binding C-type natriuretic peptide enhances chondrogenesis and osteogenesis
To enhance local drug delivery and therapeutic efficacy, we developed a novel synthetic protein by fusing a collagen-binding domain (CBD) to C-type natriuretic peptide (CNP), termed CBD-CNP. CBD-CNP localized to collagen-rich tissues and promoted bone elongation.
ORGANISM(S): Mus musculus 
2025-12-05 | E-MTAB-16154 | biostudies-arrayexpress
ProteomicsSite-specific quantification of collagen post-translational modifications reveals profound disruption of the collagen biosynthetic network upon prolyl-3-hydroxylase 1 deficiency
Type I collagen is the main structural protein in mammals and other vertebrate life forms. During the biosynthesis of collagens, prolyl-3-hydroxylase 1 (P3H1) catalyzes 3-hydroxylation of proline residues and acts as a chaperone. Deficiency of P3H1 causes Osteogenesis Imperfecta (OI), a hereditary d...
ORGANISM(S): Mus musculus (Mouse) 
2026-04-02 | PXD053751 | Pride
Glycosylation Collagen Tendon Post-translational modification (ptm) Prolyl-3-hydroxylase Hydroxyproline 
TranscriptomicsA Comparative Study of Genome Wide Transcriptional Profiles of Primary Hepatocyte in In Vitro Cultures
The liver is one of most important organs in our bodies. It performs many essential functions including metabolism, synthesis, secretion, detoxification, and storage. Hepatocytes are the principal cell type in the liver and are involved in multiple liver-specific functions. There have been several e...
ORGANISM(S): Rattus norvegicus 
2010-06-08 | E-GEOD-20659 | biostudies-arrayexpress
TranscriptomicsMadin-Darby Canine Kidney (MDCK) cells grown in 2-dimensional and 3-dimensional type I collagen culture.
In order to gain insight into epithelial morphogenesis and the influence of culture geometry on gene expression patterns, Madin Darby Canine Kidney (MDCK) epithelial cells where grown in 2-dimensional (2D) culture or 3-dimensional (3D) culture . MDCK cells cultured in 2D were plated atop a pre-soli...
ORGANISM(S): Canis lupus familiaris 
2013-06-03 | E-GEOD-28381 | biostudies-arrayexpress
TranscriptomicsUse of an activated beta-catenin to identify Wnt/beta-catenin pathway target genes in C. elegans, including a subset of collagen genes expressed in late larval development
The Wnt signaling pathway plays a fundamental role during the development of metazoans, where it functions in the regulation of diverse processes including cell fate specification, cell migration, and stem cell renewal. Activation of the beta-catenin dependent or canonical Wnt signaling pathway upr...
ORGANISM(S): Caenorhabditis elegans 
2014-05-13 | E-GEOD-51502 | biostudies-arrayexpress
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